KIF20A Gene Summary [Human]
Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF20A |
| Official Name | kinesin family member 20A [Source:HGNC Symbol;Acc:HGNC:9787] |
| Ensembl ID | ENSG00000112984 |
| Bio databases IDs | |
| Aliases | kinesin family member 20A, mitotic kinesin-like protein 2 |
| Synonyms | kinesin family member 20A, MKLP2, RAB6KIFL, RABKINESIN 6, RCM6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF20A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Kinesin motor, catalytic domain
- microtubule binding
- protein kinase binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- Rab6A binding domain
- protein binding
- Knl1 RWD C-terminal domain
- RBD_KIF20A-like
Pathways
Biological processes and signaling networks where the KIF20A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck squamous cell carcinoma
- HER2 negative hormone receptor negative breast cancer
- familial restrictive cardiomyopathy type 6
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- diffuse large B-cell lymphoma
- head and neck squamous cell cancer
role in cell
- phosphorylation in
- proliferation
- formation
- apoptosis
- growth
- morphology
- senescence
- clustering
- cytokinesis
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- Nucleus
- centrosome
- Golgi Apparatus
- microtubules
- midbody
- cell-cell contacts
- cytoplasmic bridges
- nucleoplasm
- cleavage furrow
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF20A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- cytokinesis after mitosis
- protein transport
- regulation of cytokinesis
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- spindle
- kinesin complex
- Golgi apparatus
- midbody
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein kinase binding
- microtubule motor activity
- protein binding
- microtubule binding