WDR77 Gene Summary [Human]
The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | WDR77 |
| Official Name | WD repeat domain 77 [Source:HGNC Symbol;Acc:HGNC:29652] |
| Ensembl ID | ENSG00000116455 |
| Bio databases IDs | |
| Aliases | WD repeat domain 77, methylosome protein 50 |
| Synonyms | 2610003I18RIK, 2610312E17Rik, Ac2-269, HKMT1069, LOC100911453, MEP-50, METHYLOSOME protein 50, Nbla10071, p44, p44/MEP50, RGD1310479, WD repeat domain 77 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR77 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD-like repeat
- transcription regulator
- WD40 repeats
- nuclear export signal
- transcription co-activator
- methyl-CpG binding
- nuclear localization sequence
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
role in cell
- proliferation
- phosphorylation in
- expression in
- interaction in
- transactivation in
- production in
- dimerization in
- aggregation in
- derepression in
- proliferation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDR77 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial cell proliferation involved in prostate gland development
- oocyte axis specification
- positive regulation of transcription, DNA-dependent
- positive regulation of nuclear mRNA splicing, via spliceosome
- protein polyubiquitination
- positive regulation of cell proliferation
- epithelial cell proliferation involved in prostate gland development
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
- regulation of transcription from RNA polymerase II promoter
- spliceosomal snRNP assembly
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- methylosome
- cytosol
- Cul4B-RING ubiquitin ligase complex
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity
- methyl-CpG binding