Suclg2 Gene Summary [Rat]
Enables GDP binding activity and succinate-CoA ligase (GDP-forming) activity. Involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Part of succinate-CoA ligase complex (GDP-forming). Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suclg2 |
| Official Name | succinate-CoA ligase, GDP-forming, beta subunit [Source:RGD Symbol;Acc:1305008] |
| Ensembl ID | ENSRNOG00000005686 |
| Bio databases IDs | |
| Aliases | succinate-CoA ligase, GDP-forming, beta subunit |
| Synonyms | D6Wsu120e, GBETA, G-SCS, GTPSCS, LOC105377148, Loc362404, SCS-betaG, Sucb2, succinate-CoA ligase GDP-forming subunit beta, succinate-CoA ligase GDP-forming subunit β, succinate-Coenzyme A ligase, GDP-forming, beta subunit, succinate-Coenzyme A ligase, GDP-forming, β subunit, Succinyl-coa ligase, SUCGL2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Suclg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- succinyl-CoA synthetase, beta subunit
- binding protein
- succinate-CoA ligase (GDP-forming)
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- GDP binding
- succinate-semialdehyde dehydrogenase
- CoA-ligase
- ATP-grasp domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- acute myeloid leukemia
- Alzheimer disease
- prostatic carcinoma
- prostate cancer
- pelvic organ prolapse
- astigmatism
- diabetic nephropathy
- productive infection by HIV-1
role in cell
- proliferation
- expression in
- fragmentation
- fragmentation in
- transmembrane potential
- succinylation in
- swelling in
- swelling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Suclg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tricarboxylic acid cycle
- succinate metabolic process
- succinyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- succinate-CoA ligase complex (GDP-forming)
- mitochondrion
- succinate-CoA ligase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- ATP binding
- succinate-CoA ligase (GDP-forming) activity
- protein binding
- GDP binding
- succinate-CoA ligase (ADP-forming) activity