Rpl12 Gene Summary [Rat]
Enables large ribosomal subunit rRNA binding activity. Involved in positive regulation of translational elongation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL12 (ribosomal protein L12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl12 |
| Official Name | ribosomal protein L12 [Source:RGD Symbol;Acc:1565106] |
| Ensembl ID | ENSRNOG00000016220 |
| Bio databases IDs | |
| Aliases | ribosomal protein L12 |
| Synonyms | E430018F03, L12, ribosomal protein L12, RL12, uL11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpl12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- rRNA binding
- Ribosomal protein L11, RNA binding domain
- Ribosomal protein L11/L12
- Ribosomal protein L11, N-terminal domain
- protein binding
- Ribosomal_L11
Pathways
Biological processes and signaling networks where the Rpl12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- detergent resistant lipid raft fraction
- ribosome
- Nucleus
- cytosol
- nucleoli
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rpl12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular vesicular exosome
- focal adhesion
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- cytosolic large ribosomal subunit
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- LSU rRNA binding