SUCLG2 Gene Summary [Human]
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | SUCLG2 |
| Official Name | succinate-CoA ligase GDP-forming subunit beta [Source:HGNC Symbol;Acc:HGNC:11450] |
| Ensembl ID | ENSG00000172340 |
| Bio databases IDs | |
| Aliases | succinate-CoA ligase GDP-forming subunit beta |
| Synonyms | D6Wsu120e, GBETA, G-SCS, GTPSCS, LOC105377148, Loc362404, SCS-betaG, Sucb2, succinate-CoA ligase GDP-forming subunit beta, succinate-CoA ligase GDP-forming subunit β, succinate-Coenzyme A ligase, GDP-forming, beta subunit, succinate-Coenzyme A ligase, GDP-forming, β subunit, Succinyl-coa ligase, SUCGL2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUCLG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- succinyl-CoA synthetase, beta subunit
- binding protein
- succinate-CoA ligase (GDP-forming)
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- GDP binding
- succinate-semialdehyde dehydrogenase
- CoA-ligase
- ATP-grasp domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- acute myeloid leukemia
- Alzheimer disease
- prostatic carcinoma
- prostate cancer
- pelvic organ prolapse
- astigmatism
- diabetic nephropathy
- productive infection by HIV-1
role in cell
- proliferation
- expression in
- fragmentation
- fragmentation in
- transmembrane potential
- succinylation in
- swelling in
- swelling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUCLG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tricarboxylic acid cycle
- succinate metabolic process
- succinyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- succinate-CoA ligase complex (GDP-forming)
- mitochondrion
- succinate-CoA ligase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- ATP binding
- succinate-CoA ligase (GDP-forming) activity
- protein binding
- GDP binding
- succinate-CoA ligase (ADP-forming) activity