Suclg2 Gene Summary [Mouse]
Predicted to enable GDP binding activity; succinate-CoA ligase (GDP-forming) activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Part of succinate-CoA ligase complex (GDP-forming). Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suclg2 |
| Official Name | succinate-Coenzyme A ligase, GDP-forming, beta subunit [Source:MGI Symbol;Acc:MGI:1306824] |
| Ensembl ID | ENSMUSG00000061838 |
| Bio databases IDs | |
| Aliases | succinate-Coenzyme A ligase, GDP-forming, beta subunit |
| Synonyms | D6Wsu120e, GBETA, G-SCS, GTPSCS, LOC105377148, Loc362404, SCS-betaG, Sucb2, succinate-CoA ligase GDP-forming subunit beta, succinate-CoA ligase GDP-forming subunit β, succinate-Coenzyme A ligase, GDP-forming, beta subunit, succinate-Coenzyme A ligase, GDP-forming, β subunit, Succinyl-coa ligase, SUCGL2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Suclg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- succinyl-CoA synthetase, beta subunit
- binding protein
- succinate-CoA ligase (GDP-forming)
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- GDP binding
- succinate-semialdehyde dehydrogenase
- CoA-ligase
- ATP-grasp domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- acute myeloid leukemia
- Alzheimer disease
- prostatic carcinoma
- prostate cancer
- pelvic organ prolapse
- astigmatism
- diabetic nephropathy
- productive infection by HIV-1
role in cell
- proliferation
- expression in
- fragmentation
- fragmentation in
- transmembrane potential
- succinylation in
- swelling in
- swelling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Suclg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tricarboxylic acid cycle
- succinate metabolic process
- succinyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- succinate-CoA ligase complex (GDP-forming)
- mitochondrion
- succinate-CoA ligase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- ATP binding
- succinate-CoA ligase (GDP-forming) activity
- protein binding
- GDP binding
- succinate-CoA ligase (ADP-forming) activity