Idh2 Gene Summary [Rat]
Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Idh2 |
| Official Name | isocitrate dehydrogenase (NADP(+)) 2 [Source:RGD Symbol;Acc:1597139] |
| Ensembl ID | ENSRNOG00000013949 |
| Bio databases IDs | |
| Aliases | isocitrate dehydrogenase (NADP(+)) 2 |
| Synonyms | D2HGA2, E430004F23, ICD-M, IDH, IDHM, IDP, IDPM, Isocitrate dehydrogenase, ISOCITRATE DEHYDROGENASE 2, isocitrate dehydrogenase 2 (NADP+), mitochondrial, isocitrate dehydrogenase (NADP(+)) 2, mNADP-IDH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Idh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Isocitrate/isopropylmalate dehydrogenase
- mitochondrial presequence
- isocitrate dehydrogenase (NADP)
- enzyme
- magnesium ion binding
Pathways
Biological processes and signaling networks where the Idh2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myeloproliferative neoplasm
- myeloproliferative disorder
- cancer
- leukemia
- epithelial cancer
- epithelial neoplasia
- hematologic cancer
- benign neoplasia
- neoplasia
- organismal death
role in cell
- accumulation in
- proliferation
- expression in
- production in
- phosphorylation in
- cell death
- generation in
- degradation in
- fusion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- synaptic membrane
- mitochondrial matrix
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Idh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- glyoxylate cycle
- NADP metabolic process
- isocitrate metabolic process
- tricarboxylic acid cycle
- 2-oxoglutarate metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- NAD binding
- isocitrate dehydrogenase (NADP+) activity