RNASE1 Gene Summary [Human]
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNASE1 |
| Official Name | ribonuclease A family member 1, pancreatic [Source:HGNC Symbol;Acc:HGNC:10044] |
| Ensembl ID | ENSG00000129538 |
| Bio databases IDs | |
| Aliases | ribonuclease A family member 1, pancreatic |
| Synonyms | LOC103690354,RAC1,RIB1,ribonuclease A family member 1, pancreatic,ribonuclease, RNase A family, 1 (pancreatic),RL1,RNase UpI-1,RNS1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNASE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease
- pancreatic ribonuclease
- enzyme
- protein binding
- RNase_A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- endometriosis
- small cell lung cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- weight gain
- head and neck neuroendocrine neoplasia
- keloid
- non-small cell lung carcinoma
- pituitary gland adenoma
role in cell
- apoptosis
- adhesion
- maturation
- permeability
- tyrosine phosphorylation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- membrane ruffles
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNASE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- lyase activity
- ribonuclease activity
- pancreatic ribonuclease activity