Rnase1 Gene Summary [Mouse]
Predicted to enable RNA nuclease activity. Acts upstream of or within response to bacterium. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain; integumental system; limb segment; and reproductive system. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnase1 |
| Official Name | ribonuclease, RNase A family, 1 (pancreatic) [Source:MGI Symbol;Acc:MGI:97919] |
| Ensembl ID | ENSMUSG00000035896 |
| Bio databases IDs | |
| Aliases | ribonuclease, RNase A family, 1 (pancreatic) |
| Synonyms | LOC103690354, RAC1, RIB1, ribonuclease A family member 1, pancreatic, ribonuclease, RNase A family, 1 (pancreatic), RL1, RNase UpI-1, RNS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnase1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease
- pancreatic ribonuclease
- enzyme
- protein binding
- RNase_A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- endometriosis
- small cell lung cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- weight gain
- head and neck neuroendocrine neoplasia
- keloid
- non-small cell lung carcinoma
- pituitary gland adenoma
role in cell
- apoptosis
- adhesion
- maturation
- permeability
- tyrosine phosphorylation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- membrane ruffles
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnase1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- lyase activity
- ribonuclease activity
- pancreatic ribonuclease activity