Fabp1 Gene Summary [Mouse]
Enables chromatin binding activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; cellular response to hypoxia; and positive regulation of fatty acid beta-oxidation. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; liver; and testis. Orthologous to human FABP1 (fatty acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fabp1 |
| Official Name | fatty acid binding protein 1, liver [Source:MGI Symbol;Acc:MGI:95479] |
| Ensembl ID | ENSMUSG00000054422 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 1, liver |
| Synonyms | FABPL, Fabplg, Fatty Acid Binding, fatty acid binding protein 1, fatty acid binding protein 1, liver, Fatty acid binding protein, liver, L-FABP, Lfabp-1, p14, Scp, SCP. |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fabp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- long-chain fatty acid transporter
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- chromatin binding
- antioxidant enzyme
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Fabp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- IgA nephropathy
- diabetic nephropathy
- hypercholesterolemia
- obesity
- chronic kidney disease
- protein overload nephropathy
- colon cancer
- preeclampsia
- contrast induced nephropathy
role in cell
- cell death
- proliferation
- expression in
- apoptosis
- activation in
- binding
- growth
- formation
- quantity
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- peroxisomal matrix
- cholesterol-rich microdomain
- cholesterol-poor microdomain
- perinuclear region
- Nucleus
- lysosome
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- apical cortex
- peroxisomes
- plasma
- peroxisome-enriched fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fabp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intestinal absorption
- long-chain fatty acid transport
- fatty acid transport
- positive regulation of fatty acid beta-oxidation
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to hypoxia
- cellular response to hydrogen peroxide
- response to vitamin B3
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
- macromolecular complex
- apical cortex
- peroxisomal matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- protein binding
- antioxidant activity
- bile acid binding
- chromatin binding
- phospholipid binding
- oleic acid binding
- long-chain fatty acid transporter activity