Lrp2 Gene Summary [Mouse]
Predicted to enable several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including circulatory system development; cranial skeletal system development; and vitamin D metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp2 |
| Official Name | low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794] |
| Ensembl ID | ENSMUSG00000027070 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor-related protein 2 |
| Synonyms | b2b1625.2Clo, D230004K18Rik, DBS, GP330, HEYMANN NEPHRITIS AUTOANTIGEN, LDL receptor related protein 2, low density lipoprotein receptor-related protein 2, M4, MEGALIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- insulin-like growth factor binding
- NHL repeat unit of beta-propeller proteins
- EGF_CA
- NPXY motif
- cytoplasmic domain
- ligand-binding domain
- LDLa
- chaperone binding
- hemoglobin binding
- Coagulation Factor Xa inhibitory site
- hormone binding
- ligand-dependent nuclear receptor interactor
- (S/T)xY motif
- cargo receptor activity
- signaling receptor activity
- ectodomain
- calcium ion binding
- protein binding
- low-density lipoprotein receptor binding
- Low-density lipoprotein receptor repeat class B
- PDZ-domain binding
- binding protein
- PXXP motif
- cytosolic tail domain
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Donnai-Barrow syndrome
- congenital heart disease
- proteinuria
- congenital anomaly of lung
- atelectasis
- gout
- Alzheimer disease
- hypothyroidism
- retinal dystrophy
role in cell
- proliferation
- apoptosis
- quantity
- expression in
- degradation in
- binding
- destruction
- loss
- endocytosis by
- catabolism by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- endocytic vesicle membrane
- axon component
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- apical cell surfaces
- intermicrovillar membranes
- plasma membrane extracellular face
- apical membrane
- endocytic zone
- recycling endosomes
- late endosomes
- endocytotic vesicle
- brush border
- clathrin-coated pits
- microvilli
- axons
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- pulmonary artery morphogenesis
- vagina development
- coronary artery morphogenesis
- male gonad development
- protein transport
- vitamin D metabolic process
- sensory perception of sound
- outflow tract septum morphogenesis
- beta-amyloid clearance
- protein kinase B signaling cascade
- retinoid metabolic process
- forebrain development
- neural tube closure
- transcytosis
- kidney development
- metal ion transport
- cobalamin transport
- positive regulation of oligodendrocyte progenitor proliferation
- ventricular septum development
- response to leptin stimulus
- endocytosis
- receptor-mediated endocytosis
- ventricular compact myocardium morphogenesis
- negative regulation of BMP signaling pathway
- secondary heart field specification
- aorta development
- negative regulation of apoptotic process
- cellular response to growth factor stimulus
- lipid metabolic process
- diol metabolic process
- positive regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
- lysosomal membrane
- lysosome
- dendrite
- brush border membrane
- extracellular vesicular exosome
- clathrin-coated endocytic vesicle membrane
- coated pit
- endosome lumen
- apical plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- cargo receptor activity
- calcium ion binding
- low-density lipoprotein receptor activity
- chaperone binding
- hormone binding
- SH3 domain binding
- insulin-like growth factor I binding