Slc27a2 Gene Summary [Mouse]
Enables long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within fatty acid transport; long-chain fatty acid metabolic process; and very long-chain fatty acid catabolic process. Located in endoplasmic reticulum; peroxisome; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and sensory organ. Orthologous to human SLC27A2 (solute carrier family 27 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc27a2 |
| Official Name | solute carrier family 27 (fatty acid transporter), member 2 [Source:MGI Symbol;Acc:MGI:1347099] |
| Ensembl ID | ENSMUSG00000027359 |
| Bio databases IDs | |
| Aliases | solute carrier family 27 (fatty acid transporter), member 2 |
| Synonyms | ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, solute carrier family 27 (fatty acid transporter), member 2, solute carrier family 27 member 2, Vlac, VLACS, Vlcas, VLCS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc27a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty acid transporter
- Adenylate forming domain, Class I superfamily
- enzyme binding
- protein binding
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- long-chain fatty acid transporter
- AMP-binding enzyme
- acid-thiol ligase
- CoA-ligase
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
- transporter
- phytanate-CoA ligase
Pathways
Biological processes and signaling networks where the Slc27a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- colon cancer
- diabetes mellitus
- colorectal carcinomagenesis
- androgenic alopecia
- hepatitis B virus-related hepatocellular carcinoma
- colon adenocarcinoma
role in cell
- expression in
- phosphorylation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- pH resistant lipid raft fraction
- perinuclear region
- Plasma Membrane
- Endoplasmic Reticulum
- specific granule membrane
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- peroxisome membrane
- peroxisomes
- peroxisomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc27a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty-acyl-CoA biosynthetic process
- long-chain fatty acid import
- methyl-branched fatty acid metabolic process
- long-chain fatty acid metabolic process
- fatty acid beta-oxidation
- very long-chain fatty acid catabolic process
- bile acid biosynthetic process
- fatty acid alpha-oxidation
- bile acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- cytosol
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- very long-chain fatty acid-CoA ligase activity
- ATP binding
- pristanate-CoA ligase activity
- fatty acid transporter activity
- phytanate-CoA ligase activity
- arachidonate-CoA ligase activity
- cholate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity
- enzyme binding
- long-chain fatty acid transporter activity