Cd36 Gene Summary [Mouse]
Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including amyloid fibril formation; positive regulation of intracellular signal transduction; and regulation of biosynthetic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including axial skeleton; bone; connective tissue; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule (CD36 blood group)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd36 |
| Official Name | CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] |
| Ensembl ID | ENSMUSG00000002944 |
| Bio databases IDs | |
| Aliases | CD36 molecule |
| Synonyms | BDPLT10, CD36 molecule, CD36 molecule (CD36 blood group), CHDS7, FAT, FATTY ACID TRANSLOCASE, GP3B, GP4, GPIV, PASIV, SCARB3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- cargo receptor activity
- signaling receptor activity
- fatty acid binding
- ectodomain
- lipoprotein receptor
- high-density lipoprotein binding
- low-density lipoprotein binding
- protein binding
- receptor binding
- beta-amyloid binding
- TGFbeta binding
- long-chain fatty acid transporter
- binding protein
- scavenger receptor
- cytoplasmic domain
- short-chain fatty acid uptake transporter
- transmembrane domain
- low-density lipoprotein receptor
- CD36 family
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd36 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- neoplasia
- myocardial infarction
- acute lymphoblastic leukemia
- thrombocytopenia
- rheumatoid arthritis
- psoriasis
- psoriatic arthritis
- cardiomyopathy
- fibrosis
role in cell
- expression in
- generation in
- proliferation
- differentiation
- quantity
- binding
- phosphorylation in
- production in
- apoptosis
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- raft fractions
- Golgi-enriched fraction
- detergent-soluble membrane fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- membrane surface
- cellular membrane
- actin cytoskeleton
- membrane skeleton
- vesicles
- Golgi Apparatus
- Mitochondria
- microtubules
- lipid droplets
- cytoplasmic aggregates
- specific granule membrane
- membrane ruffles
- plasma membrane extracellular face
- caveolae
- outer leaflet
- alpha granules
- sarcolemma
- membrane rafts
- brush border
- brush border membrane vesicles
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- lipid storage
- low-density lipoprotein particle mediated signaling
- positive regulation of blood coagulation
- triglyceride transport
- phagocytosis, recognition
- long-chain fatty acid transport
- phagocytosis, engulfment
- fatty acid transport
- energy homeostasis
- positive regulation of tumor necrosis factor production
- cholesterol transport
- defense response to Gram-positive bacterium
- response to stilbenoid
- low-density lipoprotein particle clearance
- plasma lipoprotein particle clearance
- negative regulation of protein import into nucleus
- apoptotic cell clearance
- positive regulation of NLRP3 inflammasome complex assembly
- receptor-mediated endocytosis
- nitric oxide-cGMP-mediated signaling pathway
- negative regulation of gene expression
- positive regulation of cell-matrix adhesion
- positive regulation of gene expression
- cellular response to hydroperoxide
- intestinal cholesterol absorption
- short-chain fatty acid transport
- regulation of removal of superoxide radicals
- positive regulation of macrophage derived foam cell differentiation
- plasma membrane long-chain fatty acid transport
- positive regulation of interleukin-6 production
- cellular response to diacyl bacterial lipopeptide
- receptor internalization
- cellular response to low-density lipoprotein particle stimulus
- regulation of lipopolysaccharide-mediated signaling pathway
- cholesterol import
- long-chain fatty acid import
- cGMP-mediated signaling
- positive regulation of phagocytosis, engulfment
- positive regulation of nitric oxide biosynthetic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell adhesion
- blood coagulation
- lipoprotein transport
- negative regulation of transcription from RNA polymerase II promoter
- production of molecular mediator involved in inflammatory response
- positive regulation of macrophage cytokine production
- MAPK cascade
- intestinal absorption
- response to fatty acid
- response to lipid
- response to linoleic acid
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of blood microparticle formation
- sensory perception of taste
- regulation of toll-like receptor signaling pathway
- regulation of protein complex assembly
- cell surface receptor signaling pathway
- fatty acid metabolic process
- elevation of cytosolic calcium ion concentration
- positive regulation of interleukin-12 production
- cellular response to lipopolysaccharide
- cellular response to lipoteichoic acid
- lipid metabolic process
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of cholesterol storage
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule membrane
- external side of plasma membrane
- phagocytic vesicle
- Golgi apparatus
- receptor complex
- plasma membrane
- cell surface
- caveola
- extracellular space
- brush border membrane
- cytoplasm
- membrane raft
- membrane
- apical plasma membrane
- endocytic vesicle membrane
- specific granule membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- cargo receptor activity
- low-density lipoprotein receptor activity
- scavenger receptor activity
- lipid binding
- high-density lipoprotein particle binding
- beta-amyloid binding
- long-chain fatty acid transporter activity
- transforming growth factor beta binding
- thrombospondin receptor activity
- protein binding
- lipoteichoic acid receptor activity
- short-chain fatty acid uptake transporter activity
- low-density lipoprotein particle binding
- lipoprotein particle binding
- Toll-like receptor binding