Raf1

Enables MAP kinase kinase kinase activity and small GTPase binding activity. Involved in cell surface receptor protein tyrosine kinase signaling pathway and nervous system development. Acts upstream of with a positive effect on type B pancreatic cell proliferation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; insulin secretion involved in cellular response to glucose stimulus; and positive regulation of macromolecule metabolic process. Located in pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study Noonan syndrome 5. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Raf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Raf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Raf1 gene, providing context for its role in the cell.