Target List
Covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.Analyzes the expression of the targeted genes.Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build.
Leukemia
Acute Leukemia of Ambiguous Lineage
ABL1, AFF1, BCR, CT45A2, ETV6, EWSR1, GPHN, KMT2A, MLLT10, MN1, NUP214, PBX1, SET, TCF3, ZNF384
Acute Lymphoblastic Leukemia (ALL)
ABL1, ABL2 (ARG), ACTN4, AFDN, AFF1, AFF3, AFF4, AGGF1, ANLN, ASNS, ATF7IP, AUTS2, BCL11B, BCL9, BCR, BTBD18, CASC5, CREBBP (CBP), CRLF2 (TSLPR), CSF1R, DDX3X, EBF1, ELL, ELN, EML1, EP300, EPOR, EPS15, ESRRB, ETV6, EWSR1, FGFR1, FGFR1OP, FLT3, FOXO4, FOXP1, FRYL, GAS7, GPHN, HLF, HNRNPUL1, INPP5D, JAK2, KMT2A, KMT2E, LNP1, MAML2, MEF2D, MLLT1, MLLT10, MLLT3, MN1, MNX1, MYB, MYC, NCOA2, NOTCH1, NUP214, NUP98, P2RY8, PAG1, PAX5, PBX1, PCM1, PDGFRB, PICALM, PML, PRDM16, RAP1GDS1, RARA, RCSD1, RUNX1 (AML1), SALL2, SET, SFPQ, SPI1, SSBP2, STIL, STMN1, TAF15, TAL1, TCF3, TCF7, TET1, TYK2, USP9X, ZBTB16, ZCCHC7, ZMIZ1, ZMYM2, ZNF384, ZNF521, ATM, BRAF, CDKN2A (P16INK4A), CREBBP (CBP), CSF3R (GM-CSFR), DNM2, EGFR (ERBB1), FBXW7, GATA2, HRAS, MAP2K1, MLH1, PAX5, PDGFRA, PTEN, SMARCB1
Acute Myeloid Leukemia (AML)
ABI1, ABI2, ABL1, AFDN, AFF1, AFF4, ALK, ANLN, ARHGAP26, ARHGEF12, BCOR, BCR, CASC5, CBFA2T3, CBFB, CBL, CCDC88C, CEP170B, CHD1, CHIC2, CREBBP (CBP), DAB2IP, DDX10, DEK, DHH, DIAPH2, ELL, EP300, EPS15, ERG, ETV6, FGFR1, FIP1L1, FLNA, FNBP1, FOXO3, FOXO4, FRYL, FUS, GAS7, GATA1, GLIS2, GPHN, HAUS1, HOXA9, HOXC11, HOXC13, HOXD13, IRF2BP2, JAK2, KAT6A, KDM5A, KIAA1524, KMT2A, LASP1, LNP1, LPP, LYN, MAML2, MECOM, MKL1, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT6, MN1, MNX1, MYB, MYH11, MYO1F, NCKIPSD, NCOA2, NF1, NPM1, NSD1, NTRK3, NUMA1, NUP214, NUP98, PAN3, PBX1, PCM1, PDGFRA, PDGFRB, PDS5A, PHF23, PICALM, PML, PRDM16, PRRX1, PSIP1, PSMA2, PTPRR, RANBP2, RARA, RBM15, RHEBL1, RPL22, RPN1, RUNX1 (AML1), RUNX1T1, SARNP, SEPT2, SEPT5, SEPT6, SEPT9, SET, SH3GL1, SORBS2, STAT5B, TAF15, TCF3, TET1, TFG, TOP1, TOP3A, TRIP11, TYK2, UBA2, USP42, WHSC1L1, WTIP, ZBTB16, ZFYVE19, ZNF384, ASXL1, ATM, BCOR, BRAF, CDKN2A (P16INK4A), CHEK2 (RAD53), CREBBP (CBP), CSF3R (GM-CSFR), DAXX, DNM2, FLT3, GATA2, IDH1, IDH2, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MAP2K1, MPL, MYC, NRAS, PBRM1, PDGFRA, PPM1D, PTEN, PTPN11, RAD21, RET, RUNX1 (AML1), SMARCB1, SRSF2, U2AF1, WT1
Acute Myelomonocytic Leukemia (AMML)
FLNA, HOXD13, NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
ABL1, ACTN4, AFF1, AFF3, AFF4, ATF7IP, BCR, BTBD18, CRLF2 (TSLPR), EPS15, ERG, ESRRB, ETV6, EWSR1, FUS, GAS7, JAK2, KMT2A, MAPRE1, MLLT1, NUP214, P2RY8, PAX5, PBX1, PCM1, RUNX1 (AML1), SET, SSBP2, TCF3, USP9X, ZNF384, ZNF521
Blast Phase Chronic Myeloid Leukemia
ABL1, BCR, ETV6, JAK2
Chronic Eosinophilic Leukemia
ACSL6, TNIP1
Chronic Lymphocytic Leukemia (CLL)
MYC, NOTCH1, BRAF, CHEK2 (RAD53), CSF3R (GM-CSFR), MAP2K1, TERT
Chronic Myeloid Leukemia (CML)
ABL1, BCR, CCDC88C, ETV6, HOXA11, HOXA13, JAK2, MECOM, MN1, NDE1, NUP98, PCM1, PDGFRB, RUNX1 (AML1), ABL1, CDKN2A (P16INK4A), CREBBP (CBP), CSF3R (GM-CSFR), FBXW7, GATA2
Chronic Myelomonocytic Leukemia (CMML)
CREBBP (CBP), ELL, ETV6, KMT2A, MN1, CSF3R (GM-CSFR), HRAS, SRSF2
Myelodysplastic Syndromes (MDS)
ABL1, ACTN4, ALK, CASC5, CREBBP (CBP), DEK, ERG, ETV6, FRYL, FUS, HOXD13, JAK2, KMT2A, LNP1, MAML2, MECOM, MLF1, MN1, MNX1, NDE1, NPM1, NUP214, NUP98, PCM1, PDGFRB, PRDM16, PTPRR, RANBP2, RUNX1 (AML1), RUNX1T1, TOP1, CDKN2A (P16INK4A), CSF3R (GM-CSFR), ETNK1, GNAS, HRAS, RAD21, SETBP1, SRSF2, U2AF1, XPO1, ZRSR2
Myeloproliferative Neoplasms
ABL1, ACSL6, BCR, ETV6, FGFR1, FGFR1OP, FIP1L1, FLT3, HOXA9, HOXD13, JAK2, LYN, MECOM, MLF1, MN1, NPM1, NUP98, PDGFRB, PRKG2, PSIP1, RARA, RUNX1 (AML1), TNIP1, ZMYM2, ABL1, ASXL1, JAK2, JAK3, KRAS, MPL, NRAS, SETBP1, SF3B1, SH2B3, SRSF2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)
ABL1, AFDN, AGGF1, ASNS, BCL11B, BCR, CASC5, DDX3X, ETV6, JAK2, KMT2A, KMT2E, MLLT1, MLLT10, NOTCH1, NUP214, PBX1, RUNX1 (AML1), SALL2, SET, SPI1, STIL, STMN1, TAL1, TCF3, TCF7
Other Leukemias
BCL11B, IKZF2, IKZF3, IRF2BP2, MYC, NPM1, PDCD1LG2, SETD2, TYK2
Chronic Neutrophilic Leukemia (CNL)
CSF3R (GM-CSFR)
Multiple Myeloma
ATM, BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), FBXW7, HRAS, MYC, PTEN, SMARCB1
Myeloid Malignancies
CBL, CBLB, DNMT3A, EZH2
Myelofibrosis
CHEK2 (RAD53), IDH1, IDH2, SRSF2
Other Myeloid Neoplasms
BRAF, CDKN2A (P16INK4A), CUX1, FBXW7, HRAS, MYD88, PTEN, STAT3
Lymphoma
Acute Lymphoblastic Lymphomas
BCL11B, CREBBP (CBP), EBF1, KMT2A, MLLT10, MYC, P2RY8, PRDM16, STIL
Anaplastic Large Cell Lymphomas
ADGRG7, ALK, ATIC, CLTC, MSN, MYC, NPM1, TFG, TPM3, TPM4, ALK, CDKN2A (P16INK4A), DNMT3A, NRAS, STAT3
Angioimmunoblastic T Cell Lymphomas
CD28, CTLA4, FIP1L1, PDGFRA, ALK, APC, ARID1A, ASXL1, ATM, BRAF, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, DNMT3A, EZH2, FBXW7, IDH2, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MED12, PLCG1, RHOA, STAT3, WT1, XPO1, ZFHX3
Burkitt Lymphomas
BCL6, MYC, PBX1, TCF3, APC, ARID1A, ATM, CD79B, CDKN2A (P16INK4A), CREBBP (CBP), FBXW7, HLA-A, ID3, KRAS, MYC, MYD88, NRAS, PAX5, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, RHOA, SRSF2
Diffuse Large B Cell Lymphomas (DLBCL)
ALK, BCL11A, BCL6, CCND3, CIITA, CLTC, IGLL5, LPP, MAPK13 (p38delta), MYC, NPM1, PIM1, REL, SQSTM1, TBL1XR1, TOMM40, TP63, ZCCHC7, ALK, AMER1, APC, ARID1A, ASXL1, ATM, B2M, BCL2, BCOR, BRAF, BTK, CD79B, CDKN2A (P16INK4A), CNOT3, CREBBP (CBP), CTNNB1, CXCR4, DNMT3A, EZH2, FBXW7, HLA-A, ID3, IDH2, IRS4, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MAP2K1, MED12, MSN, MYC, MYD88, NCOR1, NFKBIE, NOTCH2, NRAS, NSD2, PAX5, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PLCG1, POT1, PPM1D, PTEN, RGS7, RHOA, SF3B1, SMO, SRSF2, STAT3, STAT5B, STAT6, TERT, TRRAP, WT1, XPO1, ZFHX3, ZNF479
Follicular Lymphomas
AFF3, BCL2, BCL6, CIITA, MYC, TBL1XR1, TP63, AMER1, ARID1A, ATM, B2M, BCL2, BCOR, BRAF, BTK, CD79B, CDKN2A (P16INK4A), CREBBP (CBP), CXCR4, DNMT3A, EZH2, FBXW7, ID3, IDH2, KMT2D, MAP2K1, MED12, MYD88, NOTCH2, NRAS, PIK3R1 (p85-ALPHA), PPM1D, PTEN, RGS7, RHOA, SRSF2, STAT6, ZMYM3
Granulocytic Sarcomas
RUNX1 (AML1), RUNX1T1
Hodgkin Lymphomas
ALK, CIITA, JAK2, NPM1, SEC31A, ARID1A, ASXL1, B2M, BCOR, CDKN2A (P16INK4A), DNMT3A, EZH2, NFKBIE, NRAS, PAX5, PIK3R1 (p85-ALPHA), PPM1D, SF3B1
Inflammatory Myofibroblastic Tumors
ALK, DCTN1
Lymphoblastic Lymphomas
BCR, CRLF2 (TSLPR), EPOR, ETV6, FGFR1, NOTCH1, PBX1, PDGFRB, RARA, ZCCHC7
Lymphoblastic T Cell Lymphomas
BCR, ETV6, FGFR1, FIP1L1, LYN, PDGFRA
Mantle Cell Lymphomas
CCND3, MYC, ARID1A, ASXL1, ATM, B2M, BCOR, BRAF, BTK, CDKN2A (P16INK4A), CREBBP (CBP), DNMT3A, IDH2, KMT2D, KRAS, MED12, NCOR1, NFKBIE, NOTCH2, NRAS, NSD2, PAX5, POT1, PPM1D, PTEN, STAT3, TERT, ZFHX3
Mediastinal Large B Cell Lymphomas (MLBL)
CIITA, PDCD1LG2
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL6, BIRC3 (c-IAP2), CCND3, MALT1, MYC, MYD88, NOTCH2
Peripheral T Cell Lymphomas
ALK, ETV6, FGFR3, IKZF2, ITK, MYO1F, NPM1, S100A7, SYK, TBL1XR1, THAP4, TP63, VAV1, ALK, ARID1A, ASXL1, ATM, CDKN2A (P16INK4A), CTNNB1, DNMT3A, IDH2, IRS4, KIT (CD117), KMT2D, KRAS, MAP2K1, MSN, NRAS, PLCG1, PTEN, RGS7, RHOA, STAT3, STAT5B, TRRAP, XPO1, ZFHX3, ZNF479
Precursor T Cell Lymphoblastic Lymphomas
ABL1, JAK2, NUP214, PCM1, SET, CTNNB1, FBXW7, NRAS, WT1
T Cell Lymphomas
ATXN2L, BCL11B, FGFR1, IKZF2, JAK2
Other Lymphomas
BCL6, BIRC3 (c-IAP2), CBFB, CCND1, CCND3, CDK6, CHIC2, DEK, DUSP22, EIF4A1, KMT2A, MALT1, MKL1, MLF1, MLLT10, MYC, NFKB2, PICALM, PRDM16
AIDS-Related Lymphomas
EZH2
B Cell Lymphomas
ARID1A, ATM, B2M, BCL2, BCOR, BRAF, CD79B, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, CXCR4, DNMT3A, EZH2, JAK3, KIT (CD117), KMT2D, MAP2K1, MYD88, PIK3CA (p110-alpha), PPM1D, PTEN, RHOA, STAT3
Small Lymphocytic Lymphomas
ALK, APC, ARID1A, ASXL1, ATM, BCL2, BCOR, BRAF, BTK, CD79B, CDKN2A (P16INK4A), CNOT3, CREBBP (CBP), CXCR4, DNMT3A, FBXW7, GNAS, IRS4, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MAP2K1, MED12, MSN, MYC, MYD88, NCOR1, NFKBIE, NOTCH2, NRAS, PAX5, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PLCG1, POT1, PPM1D, PTEN, RGS7, SF3B1, STAT5B, STAT6, TERT, TRRAP, XPO1, ZFHX3, ZMYM3, ZNF479
Cutaneous T Cell Lymphomas
KRAS, PTEN
Diffuse Red Pulp Small B Cell Lymphomas
MYD88, NOTCH2
Enteropathy-Type T Cell Lymphomas
STAT5B
Gamma-Delta T Cell Lymphomas
STAT3, STAT5B
Hepatosplenic T Cell Lymphomas
STAT3, STAT5B
Lymphoplasmacytic Lymphomas
ARID1A, BTK, CD79B, CXCR4, DNMT3A, MYD88
Marginal Zone Lymphomas
AMER1, ARID1A, ASXL1, ATM, BRAF, CD79B, CREBBP (CBP), CXCR4, DNMT3A, EZH2, FBXW7, GNAS, JAK3, KIT (CD117), KMT2D, MAP2K1, MYD88, NFKBIE, NOTCH2, PIK3R1 (p85-ALPHA), RHOA, SRSF2, TRRAP, XPO1
Mycosis Fungoides (Sezary Syndrome)
AMER1, ARID1A, ATM, BCOR, CDKN2A (P16INK4A), DNMT3A, JAK1, JAK3, KMT2D, KRAS, NCOR1, NRAS, PIK3CA (p110-alpha), PLCG1, POT1, PTEN, STAT3, STAT5B
NK-T Cell Lymphomas
ALK, AMER1, APC, ARID1A, ASXL1, ATM, B2M, BCOR, BRAF, CTNNB1, DNMT3A, EZH2, FBXW7, HLA-A, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MED12, NCOR1, NOTCH2, NRAS, POT1, RGS7, RHOA, SMO, STAT3, STAT5B, WT1, XPO1, ZFHX3
Primary Central Nervous System Lymphomas
B2M, BCL2, CD79B, CDKN2A (P16INK4A), CXCR4, DNMT3A, HLA-A, JAK3, KIT (CD117), KRAS, MYD88, NOTCH2, POT1, STAT3, STAT5B, TERT, TRRAP, WT1
Primary Effusion Lymphomas
CDKN2A (P16INK4A), PTEN
Myelodysplastic Syndromes (MDS)
ABL1, ACTN4, ALK, CASC5, CREBBP (CBP), DEK, DIAPH2, ERG, ETV6, FGFR1, FRYL, FUS, GOT1, HOXA11, HOXA13, HOXD13, JAK2, KMT2A, LNP1, MAML2, MECOM, MLF1, MN1, MNX1, MYH11, NDE1, NPM1, NUP214, NUP98, PAN3, PCM1, PDGFRB, PRDM16, PSMA2, PTPRR, RANBP2, RUNX1 (AML1), RUNX1T1, SEPT9, SYK, TOP1, ZMYM2
Myeloproliferative Neoplasms
ABL1, ACSL6, BCR, CNTRL, ETV6, FGFR1, FGFR1OP, FIP1L1, FLT3, FOXP1, HOXA9, HOXD13, JAK2, KANK1, LYN, MECOM, MLF1, MN1, NPM1, NUP98, PCM1, PDGFRA, PDGFRB, PRKG2, PSIP1, RARA, RUNX1 (AML1), TNIP1
Other Hematological Malignancies
Eosinophilia
ETV6, FOXP1, LYN, PDGFRA
Langerhans Cell Histiocytosis
NTRK3, PLEKHA6
Plasma Cell Myelomas
ABL1, BCR
Polycythemia Vera
GTF2H3
Severe Thrombocythemia
KANK1, PDGFRB
Other Myeloid Neoplasms
KLF2, PTK2B (PYK2), SEMA6A
Commercial Control Samples
ALK, BAIAP2L1, BRAF, CCDC6, CD74, EGFR (ERBB1), EML4, ERG, ETV6, FGFR3, KIF5B, LMNA, MET, NCOA4, NTRK1, NTRK3, PAX8, PPARG, RET, ROS1, SEPT14, SLC34A2, SLC45A3, TACC3, TFG, TMPRSS2, TPM3
General Leukemia Markers
ANPEP, CD19, CD200, CD33, CD34, CD38, CR2, FOXM1, FOXO3, HOXA9, ITGA6, KIT (CD117), MS4A1, RUNX1 (AML1)
Leukemia Subtype Markers
Acute Lymphoblastic Leukemia (ALL)
ANPEP, BTG1, CASP8AP2, CD19, CD1A, CD2, CD22, CD33, CD5, CD7, CD79A, CD8A, CR2, ETV6, HLA-DRA, HLA-DRB1, IL2RA (CD25), JUN, KIT (CD117), LMO1, LMO2, LYL1, MEIS1, MME, MS4A1, MYC, PBX1, PTPRC, RB1, VEGFA, WT1
B Cell Acute Lymphoblastic Leukemia (B-ALL)
BTG1, CD300A, CD72, CD79A, CD79B, CD86, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CRLF2 (TSLPR), EBF1, ETV6, HOXA9, IKZF1, PAX5, RB1
T Cell Acute Lymphoblastic Leukemia (T-ALL)
BTK, CD27 (TNFRSF7), CD4, KCNN4, LMO1, LMO2, LYL1, MMP9, RUNX1 (AML1), SERPINI1, TAL1, THBS1 (TSP-1), TLX1, TLX3, VPREB3
Acute Myeloid Leukemia (AML)
ADGRE5 (CD97), ASS1, BAALC, BCL11B, BIRC5, CD200, CD300A, CD44, CD86, CD96, CD99, CLEC12A, ERG, FCGR2A, FLT3, HAVCR2, IL2RA (CD25), JUN, KIT (CD117), KLF4, LEF1, MECOM, MEIS1, MMP9, NPM1, PTPRC, THBS1 (TSP-1), VEGFA, WT1
Chronic Lymphocytic Leukemia (CLL)
ABCA6, AIM2, AKT1, BAX, BCL2, BIRC2 (c-IAP1), BTK, CD19, CD200, CD24, CD27 (TNFRSF7), CD5, CD79B, CXCR4, IL7, ITGA4 (CD49D), ITGAM, JUN, KCNN4, LAIR1, LEF1, MCL1, MMP9, MS4A1, ROR1, SERPINI1, SOX11, THBS1 (TSP-1), TNF, TTN, VEGFA, VPREB3, WNT3
Chronic Myeloid Leukemia (CML)
AURKA, AURKB, IL2RA (CD25), JUN, KIT (CD117), PTCH1, PTPRC
Other Leukemia Subtypes
CD72, IL2RA (CD25), SPI1
Leukemia Stem Cell & Proliferation Markers
ADGRG1, BAALC, BMI1, CD33, CD34, CD44, CD47, CD96, CD99, CLEC12A, CXCL12 (SDF1), CXCR4, ERG, FCGR2A, HAVCR2, IL2RA (CD25), IL3RA, KIT (CD117), KLF4, LAIR1, LIN28A, MYC, POU5F1 (OCT4), PTPRC, SOX2, THY1, WT1
Possible Prognostic Significance
Indicator of Clinical Outcome in Leukemia
AURKB, BAALC, BIRC5, ERG, FOXO3, GATA2, MECOM, MEIS1, RUNX1 (AML1), SPI1, WT1
Acute Lymphoblastic Leukemia (ALL)
ABCB1 (MDR1, PGY1), AKT1, ANPEP, BIRC5, CD33, CD3D, CD44, FLT3, HOXA9, IKZF1, JUN, MME, MYC, PAX5, SMYD2
B Cell Acute Lymphoblastic Leukemia (B-ALL)
ANPEP, CD33, CRLF2 (TSLPR), JUN, MS4A1
T Cell Acute Lymphoblastic Leukemia (T-ALL)
BCL11B, BMI1, LMO1, LMO2, LYL1, MYC, TAL1, TLX1, TLX3
Acute Myeloid Leukemia (AML)
ABCB1 (MDR1, PGY1), ANGPT2, BAALC, BCL2, BIRC2 (c-IAP1), BIRC5, BMI1, CCNA1, CD200, CD34, CD4, CD44, CD47, CD96, CLEC12A, CXCL12 (SDF1), CXCR4, ERG, GATA2, HAVCR2, HGF, IL2RA (CD25), IL3RA, KLF4, LEF1, MECOM, MEIS1, MN1, MYC, RUNX1 (AML1), SOX11, SOX2, SPI1, WT1, XIAP
Chronic Lymphocytic Leukemia (CLL)
ABCA6, ANGPT2, BCL2, CD24, CD38, CD69, ITGA4 (CD49D), KCNN4, LAIR1, LPL, MS4A1, MYC, NOTCH1, ROR1, SOX11, TTN, UGT2B17, VPREB3, WNT3, ZAP70
Chronic Myeloid Leukemia (CML)
AURKA, AURKB, LIN28A, MCL1, PTCH1
Chemotherapy Resistance Related
AKT1, AURKB, BAALC, BCL2, BIRC2 (c-IAP1), CD274 (PD-L1), CD274 (PD-L1), CD44, CD47, ERG, HLA-DRA, HLA-DRB1, IL3RA, MCL1, MYC, XIAP
Hypoxia & Oxidative Stress Related
ANGPT2, VEGFA
Treatment Target or Treatment Indicator
ASS1, BMI1, CASP8AP2, CD33, CD47, CD69, CD96, CDC25A, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CLEC12A, CXCR4, FLT3, FOXM1, FOXO3, HAVCR2, IL3RA, ITGAM, KLF4, LMO2, MS4A1, MYC, PTCH1, SERPINI1, SMARCA4, TAL1, ZAP70
Associated with Invasiveness or Infiltration into Central Nervous System
CXCL12 (SDF1), CXCR4, ZAP70
Minimal Residual Disease
ADGRE5 (CD97), BAALC, BCL2, CD19, CD200, CD24, CD300A, CD44, CD47, CD69, CD72, CD79B, CD86, CD99, CLEC12A, HAVCR2, IL2RA (CD25), IL3RA, ITGA6, NPM1, PBX1, WT1
Mechanistic Role in Pathogenesis
BCL11B, BCL2, BMI1, ERG, FOXM1, GATA2, HOXA9, LMO2, LPL, MEIS1, NOTCH1, PAX5, SPI1, TAL1, TLX1, TLX3, TNF, VEGFA, WT1
Expression Altered due to Genetic Alterations
Acute Lymphoblastic Leukemia (ALL)
AHI1, BCL11A, BCL2, BCL9, BRD4, CCND2, CEBPA, CEBPB, CEBPD, CEBPE, CEBPG, CRLF2 (TSLPR), EPOR, ETV6, HOXA1, ID4, IGF2BP1, IL3, IRF4, IRS4, LCK, LHX4, LMO1, LMO2, LYL1, MYB, MYC, NKX2-5, NOTCH1, OLIG2, TAL2, TLX1, TLX3
Acute Myeloid Leukemia (AML)
MECOM, NKX2-5, RANBP17, TCL1A, TLX3
Lymphoma
BCL10, BCL2, BCL3, BCL6, BCL9, CCND1, CCND2, CCND3, CD44, CDK6, ERVW-1, FCGR2B, FCRL4, FOXP1, GPR34, IRF4, KDSR, MALT1, MTCP1, MUC1 (mucin), MYC, NBEAP1, NFKB2, PAX5, PRDM16
Myelomas
FGFR3, MAF, MAFB, NSD2
Other Leukemia Subtypes & Other Genetic Alterations
BAALC, BCL11B, CRLF2 (TSLPR), ERG, KIT (CD117), LMO1, LPL, NPM1, TAL1, ZAP70