Support
icon_0328_cc_gen_hmr_bacteria-s

Chronic Myeloid Leukemia Signaling

Chronic myeloid leukemia (CML) is a biphasic disease, triggered by expression of the BCR/ABL fusion gene product in hematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into progenitors for the granulocyte/macrophage cell series and lymphocyte series. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations in addition to the expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.The BCR/ABL fusion gene encodes p210BCR/ABL; an oncoprotein has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm...

Chronic Myeloid Leukemia Signaling

Pathway Summary

Chronic myeloid leukemia (CML) is a biphasic disease, triggered by expression of the BCR/ABL fusion gene product in hematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into progenitors for the granulocyte/macrophage cell series and lymphocyte series. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations in addition to the expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.The BCR/ABL fusion gene encodes p210BCR/ABL; an oncoprotein has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm. The tyrosine kinase activity and cytoplasmic location of BCR/ABL allows the assembly of phosphorylated substrates (CBL, CRK and CRKL) in multiprotein complexes that transmit mitogenic and antiapoptotic signals via MAPK and PI3K pathways.Additional cytogenetic and molecular alterations are frequently found in patients with CML during the progression of the disease from chronic to blast phase. These genetic changes include mutations in TP53, RB and p16INK4A, or overexpression of genes such as EVI1, resulting in cell proliferation. In addition, chromosome translocation events in CML generate the chimeric oncoprotein AML1/EVI1, which like EV1 can repress the TGFβ-mediated growth inhibitory signal.

Chronic Myeloid Leukemia Signaling Genes list

Explore Genes related to Chronic Myeloid Leukemia Signaling

Products related to Chronic Myeloid Leukemia Signaling

Explore products related to Chronic Myeloid Leukemia Signaling
GeneGlobe ID: JHS-001Z | Cat. No.: | QIAseq RNA Fusion XP Panels
RNA Fusion XP Leukemia Panel
Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq
Product Specification
Copy Details
GeneGlobe ID: SBHS-137Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Leukemia
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-137Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Leukemia
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PHS-3000Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Comprehensive Cancer Research Panel
Kit containing ALL reagents (except indexes) for targeted DNA sequencing
Product Specification
Copy Details
GeneGlobe ID: JHS-3002Z | Cat. No.: | QIAseq RNA Fusion XP Panels
RNA Fusion XP Pan Heme Panel
Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq
Product Specification
Copy Details
GeneGlobe ID: PAHS-137Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Leukemia
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PHS-103Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Myeloid Neoplasms Focus Panel
Kit containing ALL reagents (except indexes) for targeted DNA sequencing
Product Specification
Copy Details
GeneGlobe ID: PHS-3100Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Comprehensive Cancer Focus Panel
Kit containing ALL reagents (except indexes) for targeted DNA sequencing
Product Specification
Copy Details
GeneGlobe ID: PHS-203Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Hematologic Malignancy Panel
Kit containing ALL reagents (except indexes) for targeted DNA sequencing
Product Specification
Copy Details
GeneGlobe ID: PHS-003Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Myeloid Neoplasms Research Panel
Kit containing ALL reagents (except indexes) for targeted DNA sequencing
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.