Target List
Hotspot Coverage
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, KIT (CD117), MAP2K1, NF2, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RB1, RET, ROS1, TSC2
Whole Coding Coverage
EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, MET, TP53 (p53)
Adenocarcinomas
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53), TSC2
Carcinomas
ALK, BRAF, CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, PIK3CA (p110-alpha), RET
Non-Small Cell Lung Cancers (NSCLC)
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)
ALK, BRAF, CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RB1, RET, TP53 (p53)
Squamous Cell Carcinomas
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53), TSC2
Other Lung Cancer Genes
ALK, BRAF, CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NF2, NRAS, NTRK1, PIK3CA (p110-alpha), RET