XCL1
XCL1 Gene Summary
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | XCL1 |
| Official Name | X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:10645] |
| Ensembl ID | ENSG00000143184 |
| Bio databases IDs | |
| Aliases | X-C motif chemokine ligand 1, lymphotactin |
| Synonyms | ATAC,Cytokine SCM-1,LPTN,LTN,LYMPHOTACTIN,SCM-1,SCM-1a,SCM-1-alpha,SCM-1-α,SCYC1,X-C motif chemokine ligand 1 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- protein homodimerization
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the XCL1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- USF1
- PF4
- SMAD4
- CXCL14
- COL6A2
- TBX22
- ZIC1
- FSTL1
- CCL21
- XCR1
disease
- colorectal cancer
- endometriosis
- rheumatoid arthritis
- Rett syndrome
- infection by lymphocytic choriomeningitis virus
regulated by
- IFNG
- lipopolysaccharide
- KIR2DS4
- NCR2
- lymphocytic choriomeningitis virus
- tetradecanoylphorbol acetate
- IL2
- ionomycin
- CD3 (complex)
- dexamethasone
regulates
- IFNG
- Ca2+
- IL2
- reporter gene
- synthetic promoter
- IL2RA
- TGF beta
- CCL18
- IL10
- cytokine
role in cell
- proliferation
- activation in
- cytotoxicity
- migration
- cell death
- apoptosis
- chemotaxis
- attraction
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the XCL1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- mature natural killer cell chemotaxis
- response to virus
- positive regulation of GTPase activity
- negative regulation of T-helper 1 cell activation
- inflammatory response
- negative regulation of interleukin-2 production
- positive regulation of immunoglobulin production in mucosal tissue
- negative regulation of transcription, DNA-dependent
- eosinophil chemotaxis
- positive regulation of B cell chemotaxis
- cellular response to interleukin-4
- positive regulation of T-helper 1 cell cytokine production
- release of sequestered calcium ion into cytosol
- positive regulation of granzyme A production
- negative regulation of interferon-gamma production
- positive regulation of thymocyte migration
- positive regulation of T-helper 2 cell cytokine production
- positive regulation of transforming growth factor beta production
- signal transduction
- positive regulation of neutrophil chemotaxis
- cell-cell signaling
- positive regulation of leukocyte chemotaxis
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of release of sequestered calcium ion into cytosol
- cellular response to transforming growth factor beta stimulus
- positive regulation of natural killer cell chemotaxis
- positive regulation of granzyme B production
- negative regulation of T cell cytokine production
- chemokine-mediated signaling pathway
- positive regulation of T cell cytokine production
- positive regulation of T cell chemotaxis
- negative regulation of T-helper 1 type immune response
- positive regulation of CD8-positive, alpha-beta T cell proliferation
- regulation of inflammatory response
- neutrophil chemotaxis
- positive regulation of T cell mediated cytotoxicity
- positive regulation of interleukin-10 production
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- protein homodimerization activity
- chemokine activity
- chemokine receptor binding