XCR1 Gene Summary [Human]
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains. The encoded protein transduces a signal by increasing the intracellular calcium ion level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Some studies have implicated a cluster of genes at 3p21.31, including this gene, as associated with COVID-19 risk. The encoded protein may also play a role in cell proliferation and migration in several types of cancer. [provided by RefSeq, Jan 2023]
Details
| Type | Protein Coding |
| Official Symbol | XCR1 |
| Official Name | X-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1625] |
| Ensembl ID | ENSG00000173578 |
| Bio databases IDs | |
| Aliases | X-C motif chemokine receptor 1 |
| Synonyms | CCXCR1, chemokine (C motif) receptor 1, GPR5, mXcr1, X-C motif chemokine receptor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XCR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the XCR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- hydronephrosis
- hepatocellular carcinoma
- liver cancer
- renal clear cell adenocarcinoma
regulates
role in cell
- trafficking
- homing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XCR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- immune response
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- chemokine-mediated signaling pathway
- release of sequestered calcium ion into cytosol
- calcium-mediated signaling
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- chemokine receptor activity