SEPTIN14
SEPTIN14 Gene Summary
SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson et al., 2007 [PubMed 17922164]).[supplied by OMIM, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SEPTIN14 |
| Official Name | septin 14 [Source:HGNC Symbol;Acc:HGNC:33280] |
| Ensembl ID | ENSG00000154997 |
| Bio databases IDs | |
| Aliases | septin 14 |
| Synonyms | 1700016K13Rik,LOC687409,SEPT14 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Pathways
Biological processes and signaling networks where the SEPTIN14 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SEPTIN3
- TCF3
- SEPTIN6
- CDC42EP4
- ANLN
- DCTN1
- NES
- SEPTIN4
- PACSIN3
- LIMK1
disease
- age-related hearing loss
regulated by
- DIO3
regulates
role in cell
- migration
- formation
- development
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- perinuclear region
- cytosol
- acrosome
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SEPTIN14 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- neuron migration
- spermatid development
- protein localization
CELLULAR COMPONENT
Where in the cell the gene product is active
- dendrite
- microtubule cytoskeleton
- cytoskeleton
- perinuclear region of cytoplasm
- cell division site
- cytoplasm
- acrosomal vesicle
- septin complex
- perikaryon
- axon
- septin ring
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- binding, bridging