PACSIN3 Gene Summary [Human]
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | PACSIN3 |
| Official Name | protein kinase C and casein kinase substrate in neurons 3 [Source:HGNC Symbol;Acc:HGNC:8572] |
| Ensembl ID | ENSG00000165912 |
| Bio databases IDs | |
| Aliases | protein kinase C and casein kinase substrate in neurons 3, syndapin III |
| Synonyms | 4921507A02Rik, 6330413E15Rik, protein kinase C and casein kinase substrate in neurons 3, SDPIII |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PACSIN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel inhibitor
- lipid binding
- cytoskeletal protein binding
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Plasma Membrane
- granules
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PACSIN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- negative regulation of endocytosis
- positive regulation of membrane protein ectodomain proteolysis
- cytoskeleton organization
- negative regulation of calcium ion transport
- regulation of endocytosis
- endocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- endosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding
- cytoskeletal protein binding
- phospholipid binding
- calcium channel inhibitor activity