Septin14 Gene Summary [Mouse]
Predicted to enable GTPase activity and molecular adaptor activity. Involved in neuron migration. Located in several cellular components, including dendrite; perikaryon; and perinuclear region of cytoplasm. Is expressed in cerebral cortex and testis. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SEPTIN14 (septin 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Septin14 |
| Official Name | septin 14 [Source:MGI Symbol;Acc:MGI:1921472] |
| Ensembl ID | ENSMUSG00000034219 |
| Bio databases IDs | |
| Aliases | septin 14 |
| Synonyms | 1700016K13Rik, LOC687409, SEPT14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Septin14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Pathways
Biological processes and signaling networks where the Septin14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- perinuclear region
- cytosol
- acrosome
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Septin14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- spermatid development
- protein localization
Cellular Component
Where in the cell the gene product is active
- dendrite
- microtubule cytoskeleton
- cytoskeleton
- perinuclear region of cytoplasm
- cell division site
- cytoplasm
- acrosomal vesicle
- septin complex
- perikaryon
- axon
- septin ring
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- binding, bridging