Mgat4a Gene Summary [Mouse]
Enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Involved in N-glycan processing. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in peroxisome. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgat4a |
| Official Name | mannoside acetylglucosaminyltransferase 4, isoenzyme A [Source:MGI Symbol;Acc:MGI:2662992] |
| Ensembl ID | ENSMUSG00000026110 |
| Bio databases IDs | |
| Aliases | mannoside acetylglucosaminyltransferase 4, isoenzyme A |
| Synonyms | 9530018I07RIK, Ab053217, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, glcNAc-T-IVa, GnT-4a, GNT-IV, GNT-IVA, LOC108353637, mannoside acetylglucosaminyltransferase 4, isoenzyme A, α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgat4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylglucosaminyltransferase
- protein homodimerization
- enzyme
- alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- glycosyltransferase
- Post-GPI attachment to proteins factor 4 and similar proteins
- alanine-glyoxylate transaminase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft palate
- cleft lip
- diabetic nephropathy
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- hyperinsulinism
- hyperglycemia
- insulin resistance
- sarcoidosis
role in cell
- expression in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum lumen
- Golgi membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgat4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- glyoxylate metabolic process
- N-glycan processing
- protein glycosylation
- protein N-linked glycosylation
Cellular Component
Where in the cell the gene product is active
- peroxisome
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- endoplasmic reticulum
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- acetylglucosaminyltransferase activity
- metal ion binding
- alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
- alanine-glyoxylate transaminase activity