Egfr Gene Summary [Mouse]
Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Egfr |
| Official Name | epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] |
| Ensembl ID | ENSMUSG00000020122 |
| Bio databases IDs | |
| Aliases | epidermal growth factor receptor |
| Synonyms | 9030024J15RIK, C-ERBB, EGFR1, EGF receptor, EGFR vIII, EGF/TGF-alpha RTK, EGF/TGF-α RTK, EGF-TK, epidermal growth factor receptor, ERBB, ERBB1, Errb1, ERRP, HER1, HER1 (EGFR), MENA, NISBD2, NNCIS, PIG61, wa-2, Wa5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Egfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Furin-like cysteine rich region
- protein-tyrosine kinase
- identical protein binding
- Grb2 binding domain
- intracytoplasmic phosphorylation site
- NPXY motif
- FU
- cytoplasmic domain
- Src phosphorylation site
- growth factor binding
- transmembrane receptor
- Ap-2 binding domain
- extracellular domain
- ubiquitin protein ligase binding
- hormone binding
- protein kinase binding
- Growth factor receptor domain IV
- calmodulin binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- ectodomain
- CR2 domain
- protein binding
- epidermal growth factor receptor
- Src-homology 2 binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- stalk region
- integrin binding
- transmembrane domain
- tyrosine kinase domain
- cytosolic tail domain
- substrate binding domain
- tyrosine phosphorylation site
- ATP-binding domain
- TM_EGFR-like
- chromatin binding
- Protein kinase domain
- ATP-binding pocket
- ligand-binding domain
- extracellular ligand binding domain
- basolateral sorting signal
- intracellular domain
- Tyrosine kinase, catalytic domain
- cytoplasmic kinase domain
- Protein kinase (unclassified specificity)
- dimerization domain
- nuclear localization sequence
- enzyme binding
- receptor binding
- autophosphorylation site
- protein tyrosine kinase activator
- phosphorylation site
- actin filament binding
- ATPase binding
- Receptor L domain
- binding protein
- kinase binding
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- Furin-like repeats
Pathways
Biological processes and signaling networks where the Egfr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Bladder Cancer Signaling
- Caveolar-mediated Endocytosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- EGF Signaling
- Ephrin A Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- ERK5 Signaling
- Estrogen Receptor Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FAK Signaling
- G Beta Gamma Signaling
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Glucocorticoid Receptor Signaling
- GNRH Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HER-2 Signaling in Breast Cancer
- NF-κB Signaling
- Non-Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- acute coronary syndrome
- non-insulin-dependent diabetes mellitus
- heart failure
- metastasis
- weight loss
- cancer
- obesity
- impaired glucose tolerance
- hepatic steatosis
phenotypes
- decreased leukocyte cell number
- abnormal aorta morphology
- abnormal aortic valve morphology
- abnormal branching involved in lung morphogenesis
- abnormal bronchiole epithelium morphology
- abnormal bronchus morphology
- abnormal cerebellum external granule cell layer morphology
- abnormal cerebral cortex morphology
- abnormal coat appearance
- abnormal colon morphology
- abnormal dorsal root ganglion morphology
- abnormal epidermal layer morphology
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum corneum morphology
- abnormal epidermis stratum granulosum morphology
- abnormal esophageal epithelium morphology
- abnormal exocrine pancreas morphology
- abnormal eye morphology
- abnormal eyelid development
- abnormal eyelid morphology
- abnormal fertility/fecundity
- abnormal filiform papillae morphology
- abnormal fungiform papillae morphology
- abnormal hair cortex keratinization
- abnormal hair cycle
- abnormal hair follicle development
- abnormal hair follicle inner root sheath morphology
- abnormal hair follicle morphology
- abnormal hair follicle orientation
- abnormal hair growth
- abnormal hair medulla
- abnormal hair shaft morphology
- abnormal hair texture
- abnormal heart left ventricle morphology
- abnormal heart valve physiology
- abnormal hepatocyte morphology
- abnormal inner cell mass morphology
- abnormal intestinal absorption
- abnormal intestine morphology
- abnormal lactation
- abnormal liver morphology
- abnormal lung development
- abnormal lung interstitium morphology
- abnormal mammary gland morphology
- abnormal maternal decidual layer morphology
- abnormal myocardial fiber morphology
- abnormal nail morphology
- abnormal olfactory bulb morphology
- abnormal outer ear morphology
- abnormal pancreas morphology
- abnormal pancreatic beta cell morphology
- abnormal placenta labyrinth morphology
- abnormal placenta morphology
- abnormal pulmonary acinus morphology
- abnormal pulmonary alveolus epithelium morphology
- abnormal pulmonary alveolus morphology
- abnormal pulmonary interalveolar septum morphology
- abnormal semilunar valve morphology
- abnormal sensory neuron innervation pattern
- abnormal skin appearance
- abnormal skin pigmentation
- abnormal submandibular gland branching morphogenesis
- abnormal terminal bronchiole morphology
- abnormal tongue epithelium morphology
- abnormal tongue morphology
- abnormal trophoblast layer morphology
- abnormal type II pneumocyte morphology
- abnormal vagina orifice morphology
- abnormal vibrissa morphology
- absent eyelids
- absent vibrissae
- alopecia
- aortic valve regurgitation
- aortic valve stenosis
- asymmetric snout
- atelectasis
- cachexia
- calcified aortic valve
- cardiac fibrosis
- cardiac hypertrophy
- cataract
- cleft palate
- corneal opacity
- corneal scarring
- curly vibrissae
- cyanosis
- decreased Purkinje cell number
- decreased alveolar lamellar body number
- decreased body size
- decreased body weight
- decreased brain size
- decreased cornea thickness
- decreased embryo size
- decreased embryo weight
- decreased fetal size
- decreased fibroblast cell migration
- decreased hair follicle number
- decreased spongiotrophoblast size
- decreased trophoblast giant cell number
- decreased ventricle muscle contractility
- dehydration
- delayed hair appearance
- dilated kidney collecting duct
- dilated respiratory conducting tubes
- dilated terminal bronchiole tubes
- disheveled coat
- disorganized pancreatic islets
- distorted hair follicle pattern
- dry skin
- embryonic lethality at implantation complete penetrance
- embryonic lethality between implantation and somite formation incomplete penetrance
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- embryonic lethality complete penetrance
- enhanced osteoblast differentiation
- enlarged aortic valve
- eyelids open at birth
- failure of eyelid fusion
- flaky skin
- fused cornea and lens
- heart left ventricle hypertrophy
- hematoma
- impaired lung alveolus development
- increased blood urea nitrogen level
- increased cardiac stroke volume
- increased circulating creatinine level
- increased curvature of guard hairs
- increased curvature of hairs
- increased foot pad pigmentation
- increased heart left ventricle size
- increased heart rate
- increased left ventricle systolic pressure
- increased pulse pressure
- increased susceptibility to Coronaviridae infection
- increased susceptibility to Coronaviridae infection induced morbidity/mortality
- lethality throughout fetal growth and development incomplete penetrance
- long snout
- long toenails
- loss of vibrissae
- mandible hypoplasia
- microphthalmia
- narrow snout
- perinatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- petechiae
- placental labyrinth hypoplasia
- plush coat
- pointed snout
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature chondrocyte differentiation
- premature death
- prenatal lethality complete penetrance
- prenatal lethality incomplete penetrance
- preweaning lethality complete penetrance
- prolonged PR interval
- prolonged RR interval
- respiratory distress
- respiratory failure
- rough coat
- short hair
- short mandible
- short vibrissae
- small Meckel's cartilage
- small cerebellum
- small pancreas
- small placenta
- sparse hair
- thick aortic valve
- thick epidermis
- thick pulmonary interalveolar septum
- thick skin
- thin cerebral cortex
- thin epidermis
- waved hair
- wavy vibrissae
- weight loss
role in cell
- expression in
- invasion by
- migration
- differentiation
- tyrosine phosphorylation in
- apoptosis
- phosphorylation in
- cell death
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear fraction
- raft fractions
- membrane fraction
- pH resistant lipid raft fraction
- glutaminergic synapse
- extranuclear space
- cell junction
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- extracellular vesicles
- Cytoplasm
- invadopodia
- cell-associated matrix
- cilia
- cell surface
- Golgi region
- Extracellular Space
- cell periphery
- intracellular space
- perinuclear region
- microvesicles
- organelle lumens
- membrane surface
- cellular membrane
- filamentous network
- Nucleus
- basal bodies
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- cell-cell contacts
- cytosol
- apical cell surfaces
- basolateral cell surfaces
- endoplasmic reticulum membrane
- membrane ruffles
- caveolar membranes
- apical membrane
- caveolae
- synaptic membrane
- basolateral membrane
- endosomal membrane
- nucleoplasm
- perinuclear space
- nuclear envelope
- early endosomes
- late endosomes
- membrane blebs
- endocytotic vesicle
- multivesicular bodies
- anchoring junction
- membrane rafts
- clathrin-coated pits
- pseudopodia
- axons
- clathrin-coated vesicles
- cell-cell adherens junctions
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Egfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- midgut development
- epidermal growth factor receptor signaling pathway
- negative regulation of protein catabolic process
- protein autophosphorylation
- neurogenesis
- tongue development
- negative regulation of epidermal growth factor receptor signaling pathway
- ovulation cycle
- cerebral cortex cell migration
- learning or memory
- positive regulation of cell growth
- epithelial cell proliferation
- hair follicle development
- ossification
- positive regulation of transcription, DNA-dependent
- positive regulation of synaptic transmission, glutamatergic
- positive regulation of epithelial cell proliferation
- positive regulation of peptidyl-serine phosphorylation
- protein insertion into membrane
- positive regulation of DNA repair
- positive regulation of cyclin-dependent protein kinase activity
- positive regulation of protein kinase C activity
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of mitotic cell cycle
- circadian rhythm
- hydrogen peroxide metabolic process
- translation
- regulation of protein kinase B signaling cascade
- positive regulation of bone resorption
- cellular response to epidermal growth factor stimulus
- cellular response to reactive oxygen species
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- positive regulation of MAP kinase activity
- viral entry into host cell
- multicellular organismal development
- ERBB2-EGFR signaling pathway
- positive regulation of vasoconstriction
- positive regulation of cell proliferation
- neuron projection morphogenesis
- positive regulation of DNA replication
- vasodilation
- positive regulation of transcription from RNA polymerase II promoter
- embryonic placenta development
- salivary gland morphogenesis
- positive regulation of smooth muscle cell proliferation
- astrocyte activation
- MAPK cascade
- cellular response to amino acid stimulus
- regulation of peptidyl-tyrosine phosphorylation
- response to UV-A
- cellular response to estradiol stimulus
- positive regulation of fibroblast proliferation
- cellular response to cadmium ion
- positive regulation of kinase activity
- lung development
- positive regulation of phosphorylation
- response to cobalamin
- positive regulation of G1/S transition of mitotic cell cycle
- response to hydroxyisoflavone
- signal transduction
- morphogenesis of an epithelial fold
- positive regulation of glial cell proliferation
- peptidyl-tyrosine autophosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- digestive tract morphogenesis
- cell surface receptor signaling pathway
- eyelid development in camera-type eye
- regulation of JNK cascade
- regulation of ERK1 and ERK2 cascade
- cellular response to mechanical stimulus
- response to calcium ion
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cellular response to xenobiotic stimulus
- positive regulation of mucus secretion
- diterpenoid metabolic process
- cellular response to dexamethasone stimulus
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- endoplasmic reticulum membrane
- basal plasma membrane
- endosome
- clathrin-coated endocytic vesicle membrane
- focal adhesion
- ruffle membrane
- receptor complex
- plasma membrane
- cell surface
- early endosome membrane
- nucleus
- nuclear membrane
- extracellular space
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- membrane raft
- cell junction
- Shc-EGFR complex
- endosome membrane
- macromolecular complex
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- double-stranded DNA binding
- integrin binding
- ATP binding
- protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase activity
- cadherin binding
- kinase binding
- protein kinase binding
- identical protein binding
- protein phosphatase binding
- chromatin binding
- epidermal growth factor binding
- epidermal growth factor-activated receptor activity
- actin filament binding
- calmodulin binding
- transmembrane signaling receptor activity
- protein binding
- ubiquitin protein ligase binding
- transmembrane receptor protein tyrosine kinase activator activity
- protein tyrosine kinase activator activity
- viral receptor activity
- MAP kinase kinase kinase activity
- ATPase binding
- enzyme binding