Dmrt1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including male germ cell proliferation; regulation of nuclear division; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including Sertoli cell development; positive regulation of male gonad development; and positive regulation of meiosis I. Located in cytoplasm and female germ cell nucleus. Is expressed in several structures, including early conceptus; gonad; gonad primordium; and mesonephros. Orthologous to human DMRT1 (doublesex and mab-3 related transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmrt1 |
| Official Name | doublesex and mab-3 related transcription factor 1 [Source:MGI Symbol;Acc:MGI:1354733] |
| Ensembl ID | ENSMUSG00000024837 |
| Bio databases IDs | |
| Aliases | doublesex and mab-3 related transcription factor 1 |
| Synonyms | CT154, DMT1, doublesex and mab-3 related transcription factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmrt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Double-sex mab3 related transcription factor 1
- DM DNA binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- tumorigenesis
- testicular carcinoma
- testicular cancer
- testicular germ cell tumor
- germ cell neoplasia
- 46, XY sex reversal type 4
- major depression
- dementia
- IgA deficiency
role in cell
- migration
- number
- expression in
- apoptosis
- differentiation
- mitosis
- formation
- pluripotency
- morphogenesis
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmrt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of male gonad development
- spermatogenesis
- cell morphogenesis
- Sertoli cell differentiation
- Sertoli cell development
- germ cell migration
- positive regulation of mitosis
- positive regulation of transcription from RNA polymerase II promoter
- male germ cell proliferation
- negative regulation of meiosis
- meiosis I
- regulation of transcription from RNA polymerase II promoter
- regulation of nodal signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- male sex determination
- sex differentiation
- oocyte development
- positive regulation of meiosis I
- male sex differentiation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- female germ cell nucleus
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity