Dram2 Gene Summary [Mouse]
Involved in photoreceptor cell maintenance. Acts upstream of or within cell population proliferation; phloem or xylem histogenesis; and retina development in camera-type eye. Located in apical plasma membrane and photoreceptor inner segment. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Used to study cone-rod dystrophy. Human ortholog(s) of this gene implicated in cone-rod dystrophy 21. Orthologous to human DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dram2 |
| Official Name | DNA-damage regulated autophagy modulator 2 [Source:MGI Symbol;Acc:MGI:1914421] |
| Ensembl ID | ENSMUSG00000027900 |
| Bio databases IDs | |
| Aliases | DNA-damage regulated autophagy modulator 2 |
| Synonyms | 2010305N14Rik, 2610318G18Rik, CORD21, DNA-damage regulated autophagy modulator 2, PRO180, TMEM77, WWFQ154 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dram2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Frag1/DRAM/Sfk1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- cone-rod dystrophy type 21
- cone-rod dystrophy
regulates
- PML-RARA
role in cell
- apoptosis
- proliferation
- differentiation
- autophagy in
- degradation in
- autophagy by
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome
- Golgi Apparatus
- apical membrane
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dram2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- photoreceptor cell maintenance
- autophagy
- apoptotic process
- regulation of autophagy
- visual perception
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- Golgi apparatus
- photoreceptor inner segment
- lysosomal membrane
- apical plasma membrane
- lysosome