Elavl1 Gene Summary [Mouse]
Enables lncRNA binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in post-transcriptional regulation of gene expression; protein import into nucleus; and regulation of stem cell population maintenance. Acts upstream of or within positive regulation of translation. Located in several cellular components, including cytoplasmic stress granule; endoplasmic reticulum; and sarcoplasm. Part of ribonucleoprotein complex. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; early conceptus; and genitourinary system. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elavl1 |
| Official Name | ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) [Source:MGI Symbol;Acc:MGI:1100851] |
| Ensembl ID | ENSMUSG00000040028 |
| Bio databases IDs | |
| Aliases | ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) |
| Synonyms | 2410055N02Rik, DKFZP667b083, ELAV1, ELAV like RNA binding protein 1, Hua, Hu antigen R, HUR, MelG, RGD:731215, RNA binding protein HuR, W91709 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elavl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- ribonucleoprotein binding domain
- RNA recognition motif (RRM) superfamily
- PKC phosphorylation site
- protein kinase binding
- RNA recognition motif
- mRNA binding
- protein binding
- RNA binding
- mRNA 3' UTR binding
- HuR Nucleocytoplasmic Shuttling domain
- double-stranded RNA binding
- hinge domain
- protein homodimerization
- RNA-binding domain
Pathways
Biological processes and signaling networks where the Elavl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- impaired glucose tolerance
- severe acute respiratory syndrome
- nonalcoholic fatty liver disease
- organismal death
- fibrosis
- colorectal cancer
- heart failure
- lung adenocarcinoma
role in cell
- differentiation
- generation in
- apoptosis
- expression in
- cellular infiltration by
- migration
- quantity
- invasion by
- formation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- polyribosome fractions
- glutaminergic synapse
- postsynaptic region
- ribosome
- Nucleus
- Endoplasmic Reticulum
- polysomes
- cytosol
- sarcoplasm
- sister chromatids
- nucleoplasm
- interchromatin granule clusters
- nuclear envelope
- cytoplasmic vesicles
- multivesicular bodies
- stress granule
- perikaryon
- axons
- paraspeckle-like structures
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elavl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA stabilization
- mRNA destabilization
- positive regulation of translation
- protein import into nucleus
- mRNA stabilization
- regulation of stem cell maintenance
- protein homooligomerization
- negative regulation of gene silencing by miRNA
- posttranscriptional gene silencing
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- sarcoplasm
- cytoplasm
- membrane
- cytoplasmic mRNA processing body
- cytosol
- cytoplasmic vesicle
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- protein kinase binding
- protein binding
- protein homodimerization activity
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- double-stranded RNA binding
- mRNA binding
- mRNA 3'-UTR binding