Hspg2 Gene Summary [Mouse]
Enables protease binding activity. Involved in receptor-mediated endocytosis. Acts upstream of or within several processes, including cardiac muscle tissue development; extracellular matrix organization; and skeletal system development. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; early conceptus; genitourinary system; and nervous system. Used to study Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; dextro-looped transposition of the great arteries; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspg2 |
| Official Name | perlecan (heparan sulfate proteoglycan 2) [Source:MGI Symbol;Acc:MGI:96257] |
| Ensembl ID | ENSMUSG00000028763 |
| Bio databases IDs | |
| Aliases | perlecan (heparan sulfate proteoglycan 2) |
| Synonyms | AABR07073181.1, AI852380, BASEMENT MEMBRANE SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE, BASEMENT MEMBRANE SPECIFIC HEPARAN sulphATE PROTEOGLYCAN CORE, ENDOREPELLIN, Heparan Sulfate Proteoglycan 2, Heparan sulphate Proteoglycan 2, HSPG, LOC100047061, LOC313641, Pcn, Per, Perlecan, perlecan (heparan sulfate proteoglycan 2), perlecan (heparan sulphate proteoglycan 2), PLC, PRCAN, SJA, SJS, SJS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Laminin B (Domain IV)
- perlecan domain
- SEA domain
- enzyme
- V domain
- EGF_CA
- Concanavalin A-like lectin/glucanases superfamily
- Ig superfamily domain
- Laminin-type epidermal growth factor-like domai
- Immunoglobulin like
- LDLa
- laminin G domain
- Immunoglobulin V-set domain
- laminin domain V
- protease binding
- LamG
- immunoglobulin domain
- Human growth factor-like EGF
- Immunoglobulin I-set domain
- protein binding
- low-density lipoprotein receptor binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- alpha dystroglycan binding domain
- laminin-like globular domain
- integrin binding
- collagen binding
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Hspg2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atherosclerosis
- Schwartz-Jampel syndrome type 1
- exencephaly
- androgenic alopecia
- bleeding
- dyssegmental dysplasia, Silverman-Handmaker type
- organismal death
- chronic allograft nephropathy
- breast cancer
role in cell
- phosphorylation in
- expression in
- apoptosis
- proliferation
- migration
- quantity
- formation
- autophagy in
- activation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Golgi lumen
- parenchymal basement membrane
- extrafibrillar region
- extracellular vesicles
- cell-associated matrix
- cell surface
- cell borders
- cell periphery
- Plasma Membrane
- apical cell surfaces
- lysosomal compartment
- microfibrils
- fibrils
- extracellular matrix
- basal lamina
- basement membrane
- glomerular basement membrane
- cartilage matrix
- endothelial basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of cell proliferation
- negative regulation of cell adhesion
- smoothened signaling pathway
- brain development
- response to xenobiotic stimulus
- receptor-mediated endocytosis
- embryo implantation
- inflammatory response
- response to hypoxia
- angiogenesis
- lipid metabolic process
- cell differentiation
- circulatory system development
- positive regulation of endothelial cell proliferation
- organ regeneration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- basement membrane
- extracellular vesicular exosome
- focal adhesion
- lysosomal lumen
- extracellular region
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- collagen V binding
- protein binding
- low-density lipoprotein particle receptor binding
- calcium ion binding
- extracellular matrix structural constituent conferring compression resistance
- beta-amyloid binding