Hnrnpa1

Predicted to enable several functions, including RNA binding activity; identical protein binding activity; and single-stranded DNA binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome. Located in nucleus. Is active in synapse. Is expressed in several structures, including 1-cell stage embryo; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in HTLV-1-associated myelopathy/tropical spastic paraparesis; amyotrophic lateral sclerosis type 20; distal myopathy 3; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Hnrnpa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpa1 gene, providing context for its role in the cell.