DRAM2 Gene Summary [Human]
The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | DRAM2 |
| Official Name | DNA damage regulated autophagy modulator 2 [Source:HGNC Symbol;Acc:HGNC:28769] |
| Ensembl ID | ENSG00000156171 |
| Bio databases IDs | |
| Aliases | DNA damage regulated autophagy modulator 2 |
| Synonyms | 2010305N14Rik, 2610318G18Rik, CORD21, DNA-damage regulated autophagy modulator 2, PRO180, TMEM77, WWFQ154 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRAM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Frag1/DRAM/Sfk1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- cone-rod dystrophy type 21
- cone-rod dystrophy
regulates
- PML-RARA
role in cell
- apoptosis
- proliferation
- differentiation
- autophagy in
- degradation in
- autophagy by
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome
- Golgi Apparatus
- apical membrane
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRAM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- photoreceptor cell maintenance
- autophagy
- apoptotic process
- regulation of autophagy
- visual perception
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- Golgi apparatus
- photoreceptor inner segment
- lysosomal membrane
- apical plasma membrane
- lysosome