Msl2 Gene Summary [Mouse]
Enables histone H2B ubiquitin ligase activity and promoter-enhancer loop anchoring activity. Involved in epigenetic regulation of gene expression and positive regulation of DNA-templated transcription. Part of MSL complex. Is active in nucleus. Is expressed in embryo. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msl2 |
| Official Name | MSL complex subunit 2 [Source:MGI Symbol;Acc:MGI:1925103] |
| Ensembl ID | ENSMUSG00000066415 |
| Bio databases IDs | |
| Aliases | MSL complex subunit 2 |
| Synonyms | E130103E02Rik, FLJ10546, KBHS, LOC108351771, MSL2L1, MSL complex subunit 2, RGD1310355, RNF184 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- chromatin binding
- enzyme
- protein binding
- DNA binding
- DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- non-insulin-dependent diabetes mellitus
- dementia
- Karayol-Borroto-Haghshenas neurodevelopmental syndrome
regulated by
- FOXA1
- H1-1
- H1-6
regulates
- TP53
- APOBEC3B
- YY1
role in cell
- DNA damage response
- degradation in
- ubiquitination in
- brefeldin A sensitivity
- non-homologous end joining in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- protein monoubiquitination
- regulation of gene expression, epigenetic
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- MSL complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding