Ywhae Gene Summary [Mouse]
Enables protein domain specific binding activity; protein phosphatase binding activity; and protein phosphatase inhibitor activity. Acts upstream of or within neuron migration; pallium development; and protein targeting. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and left ventricular noncompaction. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ywhae |
| Official Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [Source:MGI Symbol;Acc:MGI:894689] |
| Ensembl ID | ENSMUSG00000020849 |
| Bio databases IDs | |
| Aliases | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide |
| Synonyms | 14-3-3E, 14-3-3 epsilon, 14-3-3 L, 14-3-3 ε, HEL2, KCIP-1, LOC727845, MDCR, MDS, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein ε, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ε, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ε polypeptide |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ywhae often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- calcium channel inhibitor
- nuclear export signal
- 14-3-3 domain
- protein phosphatase binding
- protein binding activity, bridging
- potassium channel regulator
- phosphoprotein binding
- enzyme binding
- histone deacetylase binding
- protein domain specific binding
- protein binding
- protein kinase c inhibitor
- identical protein binding
- calcium channel regulator
- phosphoprotein amino acid binding
- protein phosphatase inhibitor activity
- binding protein
- ion channel binding
- 14-3-3 protein
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Ywhae gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- small cell lung carcinoma
- glioma formation
- hypertension
- cyanosis
- schizophrenia
- essential tremor
- Miller-Dieker lissencephaly
- psoriasis
- connective tissue disorder
role in cell
- activation in
- apoptosis
- survival
- migration
- binding in
- stabilization in
- response by
- transcription in
- signal transduction in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- glutaminergic synapse
- transition region of growth cone
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- Golgi membrane
- growth cone
- synapse
- axons
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ywhae gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- positive regulation of hippo signaling cascade
- positive regulation of protein export from nucleus
- negative regulation of toll-like receptor signaling pathway
- signal transduction
- protein localization
- cytosolic calcium ion homeostasis
- regulation of heart rate by hormone
- regulation of membrane repolarization
- hippocampus development
- cerebral cortex development
- substantia nigra development
- regulation of mitotic cell cycle
- protein targeting
- cytoplasmic pattern recognition receptor signaling pathway
- MAPK cascade
- neuron migration
- cellular response to heat
- cytoplasmic sequestering of protein
- regulation of heart rate by cardiac conduction
- protein localization in endoplasmic reticulum
- protein localization to nucleus
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrial membrane
- focal adhesion
- melanosome
- cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- identical protein binding
- protein phosphatase binding
- histone deacetylase binding
- signaling adaptor activity
- MHC class II protein complex binding
- calcium channel regulator activity
- ion channel binding
- scaffold protein binding
- RNA binding
- ubiquitin protein ligase binding
- protein binding
- protein heterodimerization activity
- cadherin binding
- phosphoserine binding
- phosphoprotein binding
- potassium channel regulator activity
- calcium channel inhibitor activity
- enzyme binding