Kat8 Gene Summary [Mouse]
Enables enzyme binding activity; histone H4K16 acetyltransferase activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of skeletal muscle satellite cell differentiation; post-embryonic hemopoiesis; and regulation of gene expression. Located in kinetochore and nuclear matrix. Part of MSL complex and NSL complex. Is active in chromosome; mitochondrion; and nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; limb; nervous system; and respiratory system. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Kat8 |
| Official Name | K(lysine) acetyltransferase 8 [Source:MGI Symbol;Acc:MGI:1915023] |
| Ensembl ID | ENSMUSG00000030801 |
| Bio databases IDs | |
| Aliases | K(lysine) acetyltransferase 8 |
| Synonyms | 2010203C02Rik, 5830450F21Rik, D7Ertd629e, hMOF, K(lysine) acetyltransferase 8, LIGOWS, lysine acetyltransferase 8, mMof, MOF, MYST-1, ZC2HC8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kat8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase domain
- histone lysine acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase
- transcription co-activator
- N-acyltransferase
- NAT_SF
- MOZ/SAS family
- enzyme binding
- transcription factor binding
- chromatin binding
- enzyme
- protein binding
- malignant brain tumor (MBT) repeat
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- N-acetyltransferase
- zinc finger domain
- acetyltransferase
- MYST family zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- hereditary disorder
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- Li-Ghorbani-Weisz-Hubshman syndrome
- Alzheimer disease
role in cell
- proliferation
- degradation in
- expression in
- phosphorylation in
- migration
- production in
- survival
- differentiation
- cell death
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Mitochondria
- chromosome
- nucleoplasm
- nuclear matrix
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kat8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- post-embryonic hemopoiesis
- negative regulation of type I interferon production
- positive regulation of gene expression, epigenetic
- positive regulation of transcription initiation from RNA polymerase II promoter
- neurogenesis
- regulation of transcription from RNA polymerase II promoter
- regulation of mRNA processing
- negative regulation of epithelial to mesenchymal transition
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- oogenesis
- regulation of autophagy
- myeloid cell differentiation
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- chromosome
- kinetochore
- NSL complex
- chromatin
- histone acetyltransferase complex
- nucleoplasm
- nucleus
- MSL complex
- mitochondrion
- nuclear matrix
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- metal ion binding
- histone acetyltransferase activity (H4-K16 specific)
- chromatin binding
- histone acetyltransferase activity (H4-K8 specific)
- H4 histone acetyltransferase activity
- histone acetyltransferase activity (H4-K5 specific)
- enzyme binding