Phex Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to vitamin D; and response to insulin-like growth factor stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in X-linked hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phex |
| Official Name | phosphate regulating endopeptidase homolog, X-linked [Source:RGD Symbol;Acc:3323] |
| Ensembl ID | ENSRNOG00000023440 |
| Bio databases IDs | |
| Aliases | phosphate regulating endopeptidase homolog, X-linked |
| Synonyms | Gy, HPDR, HPDR1, HYP, HYP1, LXHR, PEX, phosphate regulating endopeptidase homolog, X-linked, phosphate regulating endopeptidase X-linked, Phosp. reg. gene homol. to endopep. on the X chrom, XLH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phex often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- peptidase
- protein binding
- peptidase GluZincin family
- Peptidase family M13
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked dominant hypophosphatemic rickets
- hypophosphatemic rickets
- osteomalacia
- hypophosphatemia
- rickets
- organismal death
- autosomal dominant hypophosphatemic rickets
- thyroid carcinoma
- epithelial thyroid cancer
- hyperphosphatemia
role in cell
- expression in
- morphology
- mineralization
- regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phex gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- organophosphate metabolic process
- bone mineralization
- cell-cell signaling
- response to growth hormone stimulus
- odontogenesis
- bone development
- skeletal system development
- cellular response to parathyroid hormone stimulus
- proteolysis
- protein processing
- cellular response to vitamin D
- lung development
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metalloendopeptidase activity