Ret Gene Summary [Rat]
Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ret |
| Official Name | ret proto-oncogene [Source:RGD Symbol;Acc:3556] |
| Ensembl ID | ENSRNOG00000014751 |
| Bio databases IDs | |
| Aliases | ret proto-oncogene |
| Synonyms | CDHF12, CDHR16, C-RET, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET PROTO-ONCOGENE, RET receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ret often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine zipper domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase insertion domain
- RET Cadherin like domain 1
- cytoplasmic domain
- Cadherin repeat-like domain
- intracellular domain
- multidocking site
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- cysteine rich domain
- RET Cadherin like domain 4
- extracellular domain
- RET Cadherin like domain 3
- Protein kinase (unclassified specificity)
- dimerization domain
- signaling receptor activity
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- calcium ion binding
- protein binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Shc binding site
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- tyrosine kinase domain
- substrate binding domain
Pathways
Biological processes and signaling networks where the Ret gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- neoplasia
- cancer
- tumorigenesis
- precursor B-cell acute lymphoblastic leukemia
- liver cirrhosis
- metastatic non-small cell lung cancer
- metastatic follicular thyroid carcinoma
- advanced colon cancer
- thymic carcinoid tumor
role in cell
- growth
- loss
- adhesion
- apoptosis
- number
- production in
- expression in
- formation
- binding in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- endosomal membrane
- neurites
- early endosomes
- rough endoplasmatic reticulum
- perikaryon
- axons
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ret gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glial cell-derived neurotrophic factor receptor signaling pathway
- retina development in camera-type eye
- multicellular organismal development
- positive regulation of neuron maturation
- innervation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- neuron maturation
- neuron cell-cell adhesion
- axon guidance
- response to xenobiotic stimulus
- homophilic cell adhesion
- posterior midgut development
- protein phosphorylation
- response to pain
- enteric nervous system development
- MAPK cascade
- positive regulation of cell size
- regulation of axonogenesis
- positive regulation of metanephric glomerulus development
- positive regulation of transcription, DNA-dependent
- membrane protein proteolysis
- positive regulation of cell adhesion mediated by integrin
- positive regulation of kinase activity
- positive regulation of neuron projection development
- ureter maturation
- Peyer's patch morphogenesis
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- signal transduction
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- lymphocyte migration into lymphoid organs
- neural crest cell migration
- ureteric bud development
- cellular response to retinoic acid
- positive regulation of gene expression
- embryonic epithelial tube formation
- regulation of cell adhesion
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- dendrite
- early endosome
- receptor complex
- endosome membrane
- neuronal cell body
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- calcium ion binding
- signaling receptor activity