Postn Gene Summary [Rat]
Predicted to enable cell adhesion molecule binding activity; heparin binding activity; and metal ion binding activity. Involved in several processes, including bone regeneration; negative regulation of cell-substrate adhesion; and positive regulation of chemokine (C-X-C motif) ligand 2 production. Located in extracellular space and neuromuscular junction. Used to study congestive heart failure. Biomarker of artery disease (multiple); degenerative disc disease; end stage renal disease; periodontitis; and tendinitis. Orthologous to human POSTN (periostin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Postn |
| Official Name | periostin [Source:RGD Symbol;Acc:1305285] |
| Ensembl ID | ENSRNOG00000012660 |
| Bio databases IDs | |
| Aliases | periostin |
| Synonyms | A630052E07RIK, FLJ11382, OSF-2, OSF-2P1, Osteoblast-Specific Factor2, PDLPOSTN, Periostin, periostin, osteoblast specific factor, PLF, PN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Postn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fasciclin domain
- FAS1 domain
- signal peptide
- metal ion binding
- protein binding
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- lung cancer
- knee osteoarthritis
- heart disease
- diabetic nephropathy
- organismal death
- ovarian serous cystadenocarcinoma
- serous ovarian cancer
- lung metastasis
role in cell
- proliferation
- signaling in
- expression in
- phosphorylation in
- growth
- quantity
- cell viability
- migration
- adhesion
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- S-layer
- perinuclear region
- trans Golgi network
- neuromuscular junctions
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Postn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- regulation of Notch signaling pathway
- regulation of systemic arterial blood pressure
- cellular response to fibroblast growth factor stimulus
- negative regulation of substrate adhesion-dependent cell spreading
- cell adhesion
- tissue development
- response to mechanical stimulus
- cellular response to transforming growth factor beta stimulus
- response to hypoxia
- negative regulation of cell-matrix adhesion
- response to estradiol stimulus
- extracellular matrix organization
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- cellular response to tumor necrosis factor
- positive regulation of smooth muscle cell migration
- cellular response to vitamin K
Cellular Component
Where in the cell the gene product is active
- extracellular space
- trans-Golgi network
- neuromuscular junction
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- cell adhesion molecule binding
- heparin binding
- extracellular matrix structural constituent