Mgmt Gene Summary [Rat]
Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA alkylation repair; cellular response to ionizing radiation; and mammary gland epithelial cell differentiation. Predicted to be located in membrane. Predicted to be active in nucleoplasm. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgmt |
| Official Name | O-6-methylguanine-DNA methyltransferase [Source:RGD Symbol;Acc:3087] |
| Ensembl ID | ENSRNOG00000016038 |
| Bio databases IDs | |
| Aliases | O-6-methylguanine-DNA methyltransferase |
| Synonyms | AGAT, AGT, O6-ALKYLGUANINE DNA ALKYLTRANSFERASE, O-6-methylguanine-DNA methyltransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mgmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- methylated-DNA-protein-cysteine S-methyltransferase
- calcium ion binding
- active site
- enzyme
- ATase
- 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
- DNA methyltransferase
- DNA binding
Pathways
Biological processes and signaling networks where the Mgmt gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- adenoma formation
- benign neoplasia
role in cell
- apoptosis
- phosphorylation in
- proliferation
- growth
- G2/M phase
- cell death
- migration
- killing
- depletion
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear speckles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mgmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- DNA repair
- negative regulation of apoptotic process
- DNA ligation
- positive regulation of double-strand break repair
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- methyltransferase activity
- methylated-DNA-[protein]-cysteine S-methyltransferase activity
- DNA-methyltransferase activity