MGMT
MGMT Gene Summary
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Details
| Type | Processed Transcript |
| Official Symbol | MGMT |
| Official Name | O-6-methylguanine-DNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:7059] |
| Ensembl ID | ENSG00000170430 |
| Bio databases IDs | |
| Aliases | O-6-methylguanine-DNA methyltransferase, methylated-DNA--protein-cysteine methyltransferase |
| Synonyms | AGAT,AGT,O6-ALKYLGUANINE DNA ALKYLTRANSFERASE,O-6-methylguanine-DNA methyltransferase |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- methylated-DNA-protein-cysteine S-methyltransferase
- calcium ion binding
- active site
- enzyme
- ATase
- 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
- DNA methyltransferase
- DNA binding
Pathways
Biological processes and signaling networks where the MGMT gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- ESR2
- PRKCA
- SLC25A6
- histone H3
- BCL2L13
- EP300
- ACTB
- NCL
- FBL
disease
- neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- adenoma formation
- benign neoplasia
regulated by
- 26S proteasome
- mir-221 (includes others)
- fenofibrate
- dexamethasone
- TGFB1
- TP53
- IgG
- PKA
- O6-benzylguanine
- TNF
regulates
- D-glucose
- TP53
- TOP1
- double-stranded DNA
- ATM
- TFPI
- ethylene dibromide
- alkyl group
- MGMT
- 6'-O-methylguanosine
role in cell
- apoptosis
- phosphorylation in
- proliferation
- growth
- G2/M phase
- cell death
- migration
- killing
- depletion
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear speckles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MGMT gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- DNA repair
- negative regulation of apoptotic process
- DNA ligation
- positive regulation of double-strand break repair
- methylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- methyltransferase activity
- methylated-DNA-[protein]-cysteine S-methyltransferase activity
- DNA-methyltransferase activity