Tfpi Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to interleukin-1; cellular response to lipopolysaccharide; and response to estradiol. Located in extracellular space. Biomarker of atrial fibrillation; disseminated intravascular coagulation; myocardial infarction; and osteonecrosis. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfpi |
| Official Name | tissue factor pathway inhibitor [Source:RGD Symbol;Acc:61914] |
| Ensembl ID | ENSRNOG00000005039 |
| Bio databases IDs | |
| Aliases | tissue factor pathway inhibitor |
| Synonyms | A630013F22RIK, EPI, LACI, TFI, TFP1, TFPI1, tissue factor pathway inhibitor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfpi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- Heparan sulfate attachment site
- Kunitz protease inhibitor domain
- basic domain
Pathways
Biological processes and signaling networks where the Tfpi gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- malignant neoplasm
- venous thromboembolism
- plasma cell myeloma
- thrombocytopenia
- thrombosis
- pulmonary embolism
- deep vein thrombosis
- unstable angina
- portal vein thrombosis
role in cell
- cell death
- expression in
- migration
- apoptosis
- proliferation
- growth
- survival
- adhesion
- binding
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- cell surface
- intracellular space
- Plasma Membrane
- vesicles
- Golgi Apparatus
- caveolae
- cytoplasmic vesicles
- rough endoplasmatic reticulum
- extracellular matrix
- membrane rafts
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tfpi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to steroid hormone stimulus
- negative regulation of blood coagulation
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- caveola
- endoplasmic reticulum
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity