Target List
Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build
Hotspot Coverage
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, KIT (CD117), MAP2K1, NF2, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RB1, RET, ROS1, TSC2
Whole Coding Coverage
EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, MET, TP53 (p53)
Adenocarcinomas
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53), TSC2
Carcinomas
ALK, BRAF, CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, PIK3CA (p110-alpha), RET
Non-Small Cell Lung Cancers (NSCLC)
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)
ALK, BRAF, CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RB1, RET, TP53 (p53)
Squamous Cell Carcinomas
ALK, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53), TSC2
Other Lung Cancer Genes
ALK, BRAF, CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KIT (CD117), KRAS, MAP2K1, MET, NF2, NRAS, NTRK1, PIK3CA (p110-alpha), RET