BMT2 Gene Summary [Human]
Enables S-adenosyl-L-methionine binding activity. Involved in cellular response to amino acid starvation and negative regulation of TORC1 signaling. Colocalizes with GATOR1 complex and KICSTOR complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BMT2 |
| Official Name | base methyltransferase of 25S rRNA 2 homolog [Source:HGNC Symbol;Acc:HGNC:26475] |
| Ensembl ID | ENSG00000164603 |
| Bio databases IDs | |
| Aliases | base methyltransferase of 25S rRNA 2 homolog, hypothetical protein FLJ31818, S-adenosylmethionine sensor upstream of mTORC1 |
| Synonyms | B630005N14Rik, BMT2, C7orf60, FLJ31818, S-adenosylmethionine sensor upstream of mTORC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BMT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BMT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to methionine
- cellular response to amino acid starvation
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- methyltransferase activity