PRKAA1 Gene Summary [Human]
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRKAA1 |
| Official Name | protein kinase AMP-activated catalytic subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:9376] |
| Ensembl ID | ENSG00000132356 |
| Bio databases IDs | |
| Aliases | protein kinase AMP-activated catalytic subunit alpha 1, AMPK, alpha, 1 |
| Synonyms | AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPK alpha 1, Ampk catalytic subunit alpha1, AMPK α 1, C130083N04RIK, C alpha1 pka, protein kinase, AMP-activated, alpha 1 catalytic subunit, protein kinase AMP-activated catalytic subunit alpha 1, protein kinase AMP-activated catalytic subunit α 1, protein kinase, AMP-activated, α 1 catalytic subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKAA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- AMPK gamma subunit binding domain
- ATP binding
- chromatin binding
- enzyme
- Protein kinase domain
- AMPK beta subunit binding domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
- UBA domain-like superfamily
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- SNF1A/AMP-activated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- kinase binding
- binding protein
- Protein Kinases, catalytic domain
- AMPKA_C_like
Pathways
Biological processes and signaling networks where the PRKAA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Epithelial Adherens Junction Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- mTOR Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Osteoarthritis Pathway
- PPARα/RXRα Activation
- Sirtuin Signaling Pathway
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pulmonary hypertension
- glioblastoma cancer
- colorectal adenocarcinoma
- colorectal carcinomagenesis
- splenomegaly
- metastasis
- nonalcoholic fatty liver disease
- gastric carcinoma
- gastric epithelial cancer
role in cell
- migration
- translation in
- cell viability
- expression in
- phosphorylation in
- proliferation
- production in
- apoptosis
- survival
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cell borders
- Nucleus
- Plasma Membrane
- basal bodies
- cytosol
- apical membrane
- nucleoplasm
- nuclear speckles
- chromatin
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKAA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- cold acclimation
- glucose metabolic process
- cellular response to prostaglandin E stimulus
- response to hypoxia
- positive regulation of skeletal muscle tissue development
- cellular response to glucose stimulus
- positive regulation of transcription, DNA-dependent
- autophagy
- positive regulation of peptidyl-lysine acetylation
- energy homeostasis
- Wnt receptor signaling pathway
- regulation of peptidyl-serine phosphorylation
- cellular response to hypoxia
- negative regulation of TOR signaling cascade
- response to gamma radiation
- cellular response to organic nitrogen
- negative regulation of lipid catabolic process
- cholesterol biosynthetic process
- negative regulation of insulin receptor signaling pathway
- cellular response to glucose starvation
- cellular response to ethanol
- negative regulation of gene expression
- positive regulation of autophagy
- cellular response to nutrient levels
- fatty acid oxidation
- positive regulation of gene expression
- glucose homeostasis
- response to activity
- regulation of microtubule cytoskeleton organization
- positive regulation of cell proliferation
- positive regulation of cholesterol biosynthetic process
- response to UV
- regulation of vesicle-mediated transport
- protein phosphorylation
- regulation of circadian rhythm
- negative regulation of glucosylceramide biosynthetic process
- positive regulation of glycolysis
- chromatin remodeling
- cellular response to calcium ion
- cellular response to hydrogen peroxide
- bile acid and bile salt transport
- signal transduction
- fatty acid homeostasis
- lipid biosynthetic process
- fatty acid biosynthetic process
- neuron homeostasis
- rhythmic process
- negative regulation of apoptotic process
- cellular response to oxidative stress
- response to caffeine
- cellular response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- neuronal cell body
- chromatin
- apical plasma membrane
- axon
- AMP-activated protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- AMP-activated protein kinase activity
- metal ion binding
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
- tau protein binding
- cAMP-dependent protein kinase activity
- protein kinase activity
- chromatin binding
- protein serine/threonine kinase activity