MIF4GD Gene Summary [Human]
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | MIF4GD |
| Official Name | MIF4G domain containing [Source:HGNC Symbol;Acc:HGNC:24030] |
| Ensembl ID | ENSG00000125457 |
| Bio databases IDs | |
| Aliases | MIF4G domain containing, SLBP-interacting protein 1 |
| Synonyms | 1110014L05Rik, 2310075G12Rik, AD023, MIF4G domain containing, MIFD, RGD1309685, SLIP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIF4GD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIF4G domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- liver cancer
- organismal death
regulates
- histone
- CDKN1B
role in cell
- cell death
- proliferation
- stabilization in
- phosphorylation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi Apparatus
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIF4GD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- cap-dependent translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- Golgi apparatus
- nucleolus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- translation activator activity