Pnoc Gene Summary [Rat]
Predicted to enable opioid receptor binding activity and receptor ligand activity. Involved in chemical synaptic transmission; female pregnancy; and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnoc |
| Official Name | prepronociceptin [Source:RGD Symbol;Acc:3362] |
| Ensembl ID | ENSRNOG00000014231 |
| Bio databases IDs | |
| Aliases | prepronociceptin |
| Synonyms | N23K, Neuropeptide nociceptin 1, Nociceptine, N/OFQ, NOP, Npnc1, OFQ, OFQ/N, PPNOC, ppN/OFQ, prepronociceptin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnoc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vertebrate endogenous opioids neuropeptide
- receptor agonist activity
- protein binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Pnoc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- diabetic nephropathy
- hypotension
- allodynia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lung adenocarcinoma
- lung adenocarcinoma formation
- pain
- hyperalgesia
role in cell
- activation in
- chemotaxis
- binding in
- accumulation in
- binding
- inhibitory postsynaptic potential
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cellular membrane
- Plasma Membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnoc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
- neuropeptide signaling pathway
- signal transduction
- synaptic transmission
- female pregnancy
- sensory perception of pain
- sensory perception
Cellular Component
Where in the cell the gene product is active
- dendrite
- neuronal cell body
- synaptic membrane
- extracellular region
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- opioid peptide activity
- opioid receptor binding
- neuropeptide hormone activity