Oprl1 Gene Summary [Rat]
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Details
| Type | Protein Coding |
| Official Symbol | Oprl1 |
| Official Name | opioid related nociceptin receptor 1 [Source:RGD Symbol;Acc:68438] |
| Ensembl ID | ENSRNOG00000016768 |
| Bio databases IDs | |
| Aliases | opioid related nociceptin receptor 1 |
| Synonyms | KOR-3, LC132, MOR-C, Nociceptin/Orphanin FQ Receptor, NOCIR, NOP, NOPr, OFQR, OFQ receptor, OOR, opioid receptor-like 1, opioid related nociceptin receptor 1, OPRL, ORGC, ORL1, PNOCR, XOR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oprl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- nociceptin/orphanin-FQ receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Oprl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- postoperative pain
- knee osteoarthritis
- HIV infection
- acquired immunodeficiency syndrome
- chronic hepatitis C
- metabolic syndrome X
- cardiovascular disorder
- cancer
- non-insulin-dependent diabetes mellitus
role in cell
- accumulation in
- loss
- internalization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oprl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- opioid receptor signaling pathway
- negative regulation of blood pressure
- phospholipase C-activating G-protein coupled receptor signaling pathway
- negative regulation of cAMP-mediated signaling
- eating behavior
- sensory perception
- neuropeptide signaling pathway
- response to estradiol stimulus
- sensory perception of pain
- calcium-mediated signaling
- positive regulation of urine volume
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- protein binding
- nociceptin receptor activity