Pcsk2 Gene Summary [Rat]
Enables serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Located in dendrite; perikaryon; and secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcsk2 |
| Official Name | proprotein convertase subtilisin/kexin type 2 [Source:RGD Symbol;Acc:3273] |
| Ensembl ID | ENSRNOG00000005438 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 2 |
| Synonyms | 6330411F23Rik, NEC-2, PC2, Phpp-2, proprotein convertase subtilisin/kexin type 2, SPC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcsk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase domain in the S8 and S53 families
- P domain
- type VII secretion-associated serine protease mycosin
- Peptidase S8 pro-domain
- endopeptidase
- serine endopeptidase
- proprotein convertase 2
- Subtilase family
- peptidase
- Proprotein convertase P-domain
- protein binding
- pro domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- cancer
- epithelial cancer
- epithelial neoplasia
- benign neoplasia
- androgenic alopecia
- hyperplasia
- pancreatic neoplasia
- cerebral aneurysm
- hypoglycemia
role in cell
- quantity
- proliferation
- number
- apoptosis
- morphology
- differentiation
- mass
- volume
- abnormal morphology
- regeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- secretory granule lumen
- cellular membrane
- Endoplasmic Reticulum
- granules
- cytosol
- endoplasmic reticulum lumen
- trans Golgi network
- nucleoplasm
- insulin secretory granules
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- secretory granules
- perikaryon
- dendrites
- premelanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcsk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin processing
- islet amyloid polypeptide processing
- enkephalin processing
- proteolysis
- nervous system development
- protein autoprocessing
- peptide hormone processing
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- secretory granule
- intracellular membrane-bounded organelle
- membrane
- transport vesicle
- perikaryon
- neuron projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity