Lnpep Gene Summary [Rat]
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Lnpep |
| Official Name | leucyl and cystinyl aminopeptidase [Source:RGD Symbol;Acc:621752] |
| Ensembl ID | ENSRNOG00000047387 |
| Bio databases IDs | |
| Aliases | leucyl and cystinyl aminopeptidase |
| Synonyms | 2010309L07RIK, 4732490P18Rik, AT4R, AT4 receptor, CAP, FLJ39485, Gp160, IRAP, leucyl and cystinyl aminopeptidase, leucyl/cystinyl aminopeptidase, LOC100912445, LOC108348118, OTASE, Oxytocinase, P-LAP, Type 4 angiotensin receptor, Vp165 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lnpep often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase family M1 domain
- peptidase
- protein binding
- metallopeptidase
- Peptidase M1 N-terminal domain
- ERAP1-like C-terminal domain
- cytoplasmic domain
- zinc ion binding
- tankyrase binding domain
- lumenal domain
- cystinyl aminopeptidase
- aminopeptidase
- cytosolic tail domain
- membrane-proximal domain
- peptidase GluZincin family
Pathways
Biological processes and signaling networks where the Lnpep gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insulin resistance
- IgA nephropathy
- polyarticular juvenile rheumatoid arthritis
- coronary artery disease
- birdshot chorioretinopathy
role in cell
- size
- plasticity
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- high-density microsomal fractions
- endosomal fractions
- low-density microsomal fraction
- pH resistant lipid raft fraction
- cytoplasmic vesicle membrane
- cell surface
- Extracellular Space
- perinuclear region
- intracellular membranes
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- granules
- cytosol
- microsome
- endosomal compartment
- perinuclear space
- GLUT4 vesicles
- secretory granules
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lnpep gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide catabolic process
- protein catabolic process
- protein polyubiquitination
- proteolysis
- cell-cell signaling
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
- female pregnancy
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- early endosome lumen
- cytoplasm
- membrane
- cytosol
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metalloaminopeptidase activity
- peptide binding
- aminopeptidase activity
- metallopeptidase activity