Barx1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including endothelial cell differentiation; negative regulation of Wnt signaling pathway; and spleen development. Predicted to be active in nucleus. Orthologous to human BARX1 (BARX homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Barx1 |
| Official Name | BARX homeobox 1 [Source:RGD Symbol;Acc:1310884] |
| Ensembl ID | ENSRNOG00000016915 |
| Bio databases IDs | |
| Aliases | BARX homeobox 1 |
| Synonyms | BarH-like homeobox 1, BARX homeobox 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Barx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Barrett syndrome
- esophageal adenocarcinoma
- esophageal carcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- cleft lip
- digestive system disorder
- cleft palate
role in cell
- migration
- invasion by
- proliferation
- differentiation
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Barx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- digestive system development
- cell-cell signaling
- endothelial cell differentiation
- Wnt receptor signaling pathway
- spleen development
- negative regulation of Wnt receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity