BARX1 Gene Summary [Human]
This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BARX1 |
| Official Name | BARX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:955] |
| Ensembl ID | ENSG00000131668 |
| Bio databases IDs | |
| Aliases | BARX homeobox 1 |
| Synonyms | BarH-like homeobox 1, BARX homeobox 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BARX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Barrett syndrome
- esophageal adenocarcinoma
- esophageal carcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- cleft lip
- digestive system disorder
- cleft palate
role in cell
- migration
- invasion by
- proliferation
- differentiation
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BARX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- digestive system development
- cell-cell signaling
- endothelial cell differentiation
- Wnt receptor signaling pathway
- spleen development
- negative regulation of Wnt receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity