Bmp4 Gene Summary [Rat]
Enables growth factor activity and identical protein binding activity. Involved in several processes, including lung development; positive regulation of calcium ion transmembrane transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp4 |
| Official Name | bone morphogenetic protein 4 [Source:RGD Symbol;Acc:2213] |
| Ensembl ID | ENSRNOG00000009694 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 4 |
| Synonyms | BMP2B, BMP2B1, BOMPR4A, bone morphogenetic protein 4, MCOPS6, OFC11, ZYME |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- chemoattractant
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- receptor binding
- cytokine
- heparin binding
- identical protein binding
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Bmp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- TGF-β Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer of the oral cavity
- neoplasia
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- metastasis
- colorectal cancer
- syndromic microphthalmia 6
- growth failure
- polydactyly
role in cell
- activation in
- migration
- expression in
- recruitment in
- upregulation in
- apoptosis
- production in
- accumulation in
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- vesicles
- endoplasmic reticulum lumen
- myelin sheath
- extracellular matrix
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cranial suture morphogenesis
- endoderm development
- post-embryonic development
- positive regulation of programmed cell death
- hemopoietic progenitor cell differentiation
- anterior/posterior axis specification
- positive regulation of collagen biosynthetic process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of primary miRNA processing
- cellular response to BMP stimulus
- kidney development
- mesonephros development
- glomerular capillary formation
- positive regulation of epithelial cell proliferation
- regulation of protein import into nucleus
- positive regulation of branching involved in lung morphogenesis
- aortic valve morphogenesis
- mammary gland formation
- pulmonary valve morphogenesis
- lens induction in camera-type eye
- prostatic bud formation
- positive regulation of ossification
- cardiac right ventricle morphogenesis
- nephric duct formation
- negative regulation of myoblast differentiation
- negative regulation of epithelial cell proliferation
- endochondral ossification
- negative regulation of metanephric comma-shaped body morphogenesis
- negative regulation of metanephric S-shaped body morphogenesis
- negative regulation of T cell differentiation in thymus
- telencephalon development
- negative regulation of immature T cell proliferation in thymus
- negative regulation of cell proliferation
- muscular septum morphogenesis
- positive regulation of cell proliferation
- chondrocyte differentiation
- negative regulation of cell cycle
- lung vasculature development
- regulation of smooth muscle cell differentiation
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- apoptotic process involved in endocardial cushion morphogenesis
- cardiac septum development
- lung morphogenesis
- outflow tract septum morphogenesis
- positive regulation of smooth muscle cell proliferation
- membranous septum morphogenesis
- smooth muscle cell differentiation
- negative regulation of glomerular mesangial cell proliferation
- neuron fate commitment
- osteoblast differentiation
- positive regulation of SMAD protein import into nucleus
- negative regulation of mitosis
- sinoatrial node development
- embryonic cranial skeleton morphogenesis
- type B pancreatic cell development
- ureter morphogenesis
- positive regulation of BMP signaling pathway
- metanephros development
- ureteric bud development
- branching involved in ureteric bud morphogenesis
- positive regulation of protein phosphorylation
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of endothelial cell proliferation
- intermediate mesodermal cell differentiation
- trachea formation
- epithelial tube branching involved in lung morphogenesis
- positive regulation of protein binding
- epithelial-mesenchymal cell signaling
- branching involved in prostate gland morphogenesis
- positive regulation of epidermal cell differentiation
- positive chemotaxis
- transcription from RNA polymerase II promoter
- bud elongation involved in lung branching
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- negative regulation of prostatic bud formation
- positive regulation of endothelial cell differentiation
- regulation of branching involved in prostate gland morphogenesis
- lymphoid progenitor cell differentiation
- renal system process
- negative regulation of striated muscle tissue development
- embryonic digit morphogenesis
- lung alveolus development
- heart morphogenesis
- heart induction
- negative regulation of thymocyte apoptotic process
- BMP signaling pathway
- regulation of cell fate commitment
- monocyte differentiation
- cardiac muscle cell differentiation
- embryonic hindlimb morphogenesis
- positive regulation of bone mineralization
- macrophage differentiation
- tendon cell differentiation
- dorsal/ventral neural tube patterning
- positive regulation of protein localization to nucleus
- deltoid tuberosity development
- positive regulation of cardiac muscle fiber development
- embryonic skeletal joint morphogenesis
- trachea development
- bronchus development
- mesodermal cell fate determination
- pituitary gland development
- positive regulation of p38MAPK cascade
- negative regulation of gene expression
- secondary heart field specification
- erythrocyte differentiation
- positive regulation of gene expression
- positive regulation of cartilage development
- telencephalon regionalization
- bud dilation involved in lung branching
- endocardial cushion development
- odontogenesis of dentin-containing tooth
- epithelial to mesenchymal transition involved in endocardial cushion formation
- odontogenesis
- negative regulation of glomerulus development
- negative regulation of branching involved in ureteric bud morphogenesis
- epithelial cell proliferation involved in lung morphogenesis
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- neural tube closure
- negative regulation of mesenchymal cell proliferation involved in ureter development
- specification of organ position
- germ cell development
- coronary vasculature development
- smooth muscle tissue development
- regulation of odontogenesis of dentin-containing tooth
- auditory receptor cell differentiation
- positive regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of chondrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- chemoattractant activity
- heparin binding
- cytokine activity
- BMP receptor binding